Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
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Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteinsA metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertasesTwo independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furinIsolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytesToxin-based targeted therapy for malignant brain tumorsToxin-based therapeutic approachesDomain Flexibility Modulates the Heterogeneous Assembly Mechanism of Anthrax Toxin Protective AntigenThe Hsp90 machinery facilitates the transport of diphtheria toxin into human cellsCell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entryDistinct roles for the N- and C-terminal regions in the cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from cabbage butterfly, against mammalian cells.Role of trypsin-like cleavage at arginine 192 in the enzymatic and cytotonic activities of Escherichia coli heat-labile enterotoxinFusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells.Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteasesFurin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells.A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.Clostridium septicum alpha-toxin is proteolytically activated by furin.Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development.The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.Generation and characterization of non-competitive furin-inhibiting nanobodies.The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals.Mechanism of Borna disease virus entry into cells.Secreted antiviral entry inhibitory (SAVE) peptides for gene therapy of HIV infection.JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation.Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin.The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.Retrieval of TGN proteins from the cell surface requires endosomal acidification.Inclusion of a furin-sensitive spacer enhances the cytotoxicity of ribotoxin restrictocin containing recombinant single-chain immunotoxinsLack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo.Zinc metalloproteinase ProA directly activates Legionella pneumophila PlaC glycerophospholipid:cholesterol acyltransferaseConstruction, expression and characterization of chimaeric toxins containing the ribonucleolytic toxin restrictocin: intracellular mechanism of action.Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication.Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered alpha 2-macroglobulin containing a furin recognition sequence in the bait region.Topography of the hydrophilic helices of membrane-inserted diphtheria toxin T domain: TH1-TH3 as a hydrophilic tetherPACE4: a subtilisin-like endoprotease with unique properties.
P2860
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P2860
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
@en
type
label
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
@en
prefLabel
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
@en
P2093
P1476
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
@en
P2093
P304
26461-26465
P407
P577
1993-12-01T00:00:00Z