A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop. - Wikidata - awgldk - TriplyDB

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop.

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop.

http://www.wikidata.org/entity/Q41517167

about

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome Mitochondrial DNA replication: a PrimPol perspective.Nascent RNA transcripts facilitate the formation of G-quadruplexes.Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints.A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.A model for transcription initiation in human mitochondria Maintaining ancient organelles: mitochondrial biogenesis and maturation.Ups and Downs of Poised RNA Polymerase II in B-Cells.Emerging role of RNA•DNA hybrids in C9orf72-linked neurodegeneration.RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents.Guanine quadruplex structures localize to heterochromatin.Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control.Multiple G-quartet structures in pre-edited mRNAs suggest evolutionary driving force for RNA editing in trypanosomes.Animal Mitochondrial DNA Replication.Putative RNA-Directed Adaptive Mutations in Cancer Evolution.No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline.Co-transcriptional production of RNA-DNA hybrids for simultaneous release of multiple split functionalities.Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif.G-quadruplex structures mark human regulatory chromatin.Non-Canonical Replication Initiation: You're Fired!RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms.Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.R-loops and initiation of DNA replication in human cells: a missing link?Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity.DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol.Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter.TEFM is a potent stimulator of mitochondrial transcription elongation in vitro.The human mitochondrial transcription factor A is a versatile G-quadruplex binding protein.Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element.Mitochondrial biology. Replication-transcription switch in human mitochondria.Relationships between the winding angle, the characteristic radius, and the torque for a long polymer chain wound around a cylinder: implications for RNA winding around DNA during transcription.Mechanism of Transcription Anti-termination in Human Mitochondria.Genome evolution is driven by gene expression-generated biophysical constraints through RNA-directed genetic variation: A hypothesis.Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.Mitochondrial DNA replication in mammalian cells: overview of the pathway A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL

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A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop.

http://www.wikidata.org/entity/Q41517167

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

A hybrid G-quadruplex structur ...... y of the mitochondrial R-loop.

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type

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A hybrid G-quadruplex structur ...... y of the mitochondrial R-loop.

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A hybrid G-quadruplex structur ...... y of the mitochondrial R-loop.

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Nucleic Acids Research

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A hybrid G-quadruplex structur ...... y of the mitochondrial R-loop.

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Claes M Gustafsson

http://www.w3.org/2001/XMLSchema#string

Fredrik Westerlund

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Jay P Uhler

http://www.w3.org/2001/XMLSchema#string

Paulina H Wanrooij

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Yonghong Shi

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of parallel quadruplexes from human telomeric DNA

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination

TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein

Reconstitution of a minimal mtDNA replisome in vitro

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

tRNA punctuation model of RNA processing in human mitochondria

The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substrates

Mechanisms and implications of transcription blockage by guanine-rich DNA sequences.

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10334-10344

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10.1093/NAR/GKS802

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20

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40

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Maria Falkenberg

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2012-09-10T00:00:00Z

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230829736

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22965135

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3488243

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