Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production.
about
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox statehRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear regionHeterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication.Small molecules targeting viral RNAAntiviral activity of geneticin against dengue virus.Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin BThe crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variabilitySolution structure of the tobramycin-RNA aptamer complexReal-time kinetics of HIV-1 Rev-Rev response element interactions. Definition of minimal binding sites on RNA and protein and stoichiometric analysisRational optimization of a HIV-1 Tat inhibitor: rapid progress on combinatorial lead structuresDevelopment of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motifSynthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response elementDecoy approach using RNA-DNA chimera oligonucleotides to inhibit the regulatory function of human immunodeficiency virus type 1 Rev proteinFunctional and Structural Analysis of a Highly-Expressed Yersinia pestis Small RNA following Infection of Cultured MacrophagesQuantum-dot-based nanosensor for RRE IIB RNA-Rev peptide interaction assay.Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology.Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.Chemical approaches to control gene expression.A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assemblySpecific binding of Hoechst 33258 to site 1 thymidylate synthase mRNA.Human immunodeficiency virus gene regulation as a target for antiviral chemotherapy.Aminoglycosides: activity and resistance.p53 binds selectively to the 5' untranslated region of cdk4, an RNA element necessary and sufficient for transforming growth factor beta- and p53-mediated translational inhibition of cdk4.Recognition of a cognate RNA aptamer by neomycin B: quantitative evaluation of hydrogen bonding and electrostatic interactions.Saccharide-RNA recognition.Correction of genetic disease by making sense from nonsense.Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.Translation of hepatitis C virus RNA.Neomycin-neomycin dimer: an all-carbohydrate scaffold with high affinity for AT-rich DNA duplexes.Recognition of HIV TAR RNA by triazole linked neomycin dimers.Emerging themes in medicinal glycoscience.Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.Sequence-specific interaction between HIV-1 matrix protein and viral genomic RNA revealed by in vitro genetic selection.Inhibition of protein synthesis by aminoglycoside-arginine conjugates.Antibody targeted therapeutics for lymphoma: new focus on the CD22 antigen and RNA.Reverse genetics approaches to combat pathogenic arenavirusesYeast glycosylation mutants are sensitive to aminoglycosides.RNA-acting antibiotics: in-vitro selection of RNA aptamers for the design of new bioactive molecules less susceptible to bacterial resistance.RNA tertiary structure of the HIV RRE domain II containing non-Watson-Crick base pairs GG and GA: molecular modeling studies.Nonviral and viral delivery of a human immunodeficiency virus protective gene into primary human T cells
P2860
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P2860
Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Small molecules that selective ...... function and viral production.
@en
type
label
Small molecules that selective ...... function and viral production.
@en
prefLabel
Small molecules that selective ...... function and viral production.
@en
P2093
P1433
P1476
Small molecules that selective ...... function and viral production.
@en
P2093
P304
P356
10.1016/0092-8674(93)90720-B
P407
P577
1993-09-01T00:00:00Z