Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? - Wikidata - awgldk - TriplyDB

Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?

Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?

http://www.wikidata.org/entity/Q41557551

about

Statins in Asthma: Potential Beneficial Effects and Limitations Statins as potential therapeutic drug for asthma?Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial.Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?Novel therapeutic strategies for adult obese asthmatics.Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Role of arginase in vessel wall remodeling.Statin use and asthma control in patients with severe asthma.Is serum cholesterol a risk factor for asthma?Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use.Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.A systematic review of statin efficacy in asthma.Asthma therapy and its effect on airway remodelling.Could simvastatin be considered as a potential therapy for chronic lung diseases? A debate on the pros and cons.Anti-asthmatic effect of pitavastatin through aerosol inhalation is associated with CD4+ CD25+ Foxp3+ T cells in an asthma mouse model.Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells.Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins.Statin therapy does not improve lung function in asthma: a meta-analysis of randomized controlled trials.Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma.Innovations in asthma therapy: is there a role for inhaled statins?Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice

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P2860

Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?

http://www.wikidata.org/entity/Q41557551

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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Simvastatin inhibits goblet ce ...... eatment for airway remodeling?

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J.TRSL.2010.09.003

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Translational Research

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Simvastatin inhibits goblet ce ...... eatment for airway remodeling?

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Amir A Zeki

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Jennifer M Bratt

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Jerold A Last

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Michelle Rabowsky

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Nicholas J Kenyon

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P2860

Pleiotropic effects of statins

Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway

Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance.

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.

Remodeling in asthma and chronic obstructive lung disease.

Beyond lipid-lowering: effects of statins on endothelial nitric oxide.

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.

An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.

Potential therapeutic role for statins in respiratory disease.

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335-349

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10.1016/J.TRSL.2010.09.003

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