Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. - Wikidata - awgldk - TriplyDB

Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level.

Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level.

http://www.wikidata.org/entity/Q41563633

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A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes Ubiquitination and deubiquitination of REST and its roles in cancers Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism Varying levels of complexity in transcription factor binding motifs.REST and CoREST modulate neuronal subtype specification, maturation and maintenance.Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation.Non-consensus GLI binding sites in Hedgehog target gene regulation.Variable structure motifs for transcription factor binding sites.Most transcription factor binding sites are in a few mosaic classes of the human genome.Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution.Why does binding of proteins to DNA or proteins to proteins not necessarily spell function?Comparison of REST cistromes across human cell types reveals common and context-specific functions Tree-based position weight matrix approach to model transcription factor binding site profiles.Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions.Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions.The critical role of protein arginine methyltransferase prmt8 in zebrafish embryonic and neural development is non-redundant with its paralogue prmt1.Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer.Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast Coassembly of REST and its cofactors at sites of gene repression in embryonic stem cells.Significant expansion of the REST/NRSF cistrome in human versus mouse embryonic stem cells: potential implications for neural development REST/NRSF Knockdown Alters Survival, Lineage Differentiation and Signaling in Human Embryonic Stem Cells.REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors.Epigenetic mechanisms in stroke and epilepsy.REST represses a subset of the pancreatic endocrine differentiation program.The RE1 binding protein REST regulates oligodendrocyte differentiation.The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit Regulation of non-coding RNA networks in the nervous system--what's the REST of the story?Impulse control: temporal dynamics in gene transcription.The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.REST: transcriptional and epigenetic regulator.Tailoring the models of transcription.RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal/endocrine function.Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI).Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression.The Importance of REST for Development and Function of Beta Cells.Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(β-TRCP) in neuroblastoma cells.Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability.

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P2860

Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level.

http://www.wikidata.org/entity/Q41563633

description

2009 nî lūn-bûn

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2009年の論文

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Functional diversity for REST ...... ies at the DNA sequence level.

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Functional diversity for REST ...... ies at the DNA sequence level.

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Functional diversity for REST ...... ies at the DNA sequence level.

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Genome Research

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Functional diversity for REST ...... ies at the DNA sequence level.

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P2093

Cordelia F Langford

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Pawandeep Dhami

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Robert M Andrews

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Shane C Dillon

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Thomas A Down

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P2860

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

A zinc finger protein that represses transcription of the human MHC class II gene, DPA

NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin

The landscape of histone modifications across 1% of the human genome in five human cell lines

NestedMICA: sensitive inference of over-represented motifs in nucleic acid sequence

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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994-1005

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10.1101/GR.089086.108

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6

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19

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Alexander W Bruce

Andrés J López-Contreras

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2009-04-28T00:00:00Z

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24376325

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19401398

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2694481

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