Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I.
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Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-IAmyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosisDisruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan.Conformation of dimeric apolipoprotein A-I milano on recombinant lipoprotein particles.Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distributionApolipoprotein A-I and its mimetics for the treatment of atherosclerosis.Secondary structure changes in ApoA-I Milano (R173C) are not accompanied by a decrease in protein stability or solubility.Effects of disulfide bond formation and protein helicity on the aggregation of activating transcription factor 5High Density Lipoprotein and it's DysfunctionMolecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.Mechanisms responsible for the compositional heterogeneity of nascent high density lipoprotein.HDL as a biomarker, potential therapeutic target, and therapyAdvancing therapy for hypercholesterolemia.Lipid-free Apolipoprotein A-I Structure: Insights into HDL Formation and Atherosclerosis Development.The dual nature of HDL: Anti-Inflammatory and pro-Inflammatory.Apolipoprotein A-I: the dual face of a protein.Influence of C-terminal α-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality.Tweaking the cholesterol efflux capacity of reconstituted HDL.The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils.Spectroscopic Characterization of Structural Changes in Membrane Scaffold Proteins Entrapped within Mesoporous Silica Gel Monoliths.Influence of N-terminal helix bundle stability on the lipid-binding properties of human apolipoprotein A-I.Effects of the Iowa and Milano mutations on apolipoprotein A-I structure and dynamics determined by hydrogen exchange and mass spectrometry.Expressed protein ligation-mediated template protein extension.Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano.Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice.Imaging apolipoprotein AI in vivo.Analysis of lipid phase behavior and protein conformational changes in nanolipoprotein particles upon entrapment in sol-gel-derived silica.Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity.A translational evidence for cholesteryl ester transfer protein modulation by glucocorticoids: A time for reflection.The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging.Primary genetic disorders affecting high density lipoprotein (HDL)
P2860
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P2860
Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Structural and functional cons ...... ) in human apolipoprotein A-I.
@en
type
label
Structural and functional cons ...... ) in human apolipoprotein A-I.
@en
prefLabel
Structural and functional cons ...... ) in human apolipoprotein A-I.
@en
P2093
P2860
P1476
Structural and functional cons ...... ) in human apolipoprotein A-I.
@en
P2093
Daniel J Rader
Eric T Alexander
Hiroyuki Saito
Masafumi Tanaka
Momoe Kono
P2860
P304
P356
10.1194/JLR.M800578-JLR200
P577
2009-03-24T00:00:00Z