about
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPPDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2Mechanism of regulation of the Epac family of cAMP-dependent RapGEFsReducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQPvdP is a tyrosinase that drives maturation of the pyoverdine chromophore in Pseudomonas aeruginosaQuorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1.Stimulation of gene induction and cell growth by the Ras effector RlfA highly active adipyl-cephalosporin acylase obtained via rational randomization.Lipase expression in Pseudomonas alcaligenes is under the control of a two-component regulatory systemA novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.The multiple signaling systems regulating virulence in Pseudomonas aeruginosa.Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor.Targeting AML through DR4 with a novel variant of rhTRAILEnacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome.DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.Activation of the small GTPase Ral in platelets.Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model.Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design.Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade.Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors.Assessing Pseudomonas virulence with nonmammalian host: Galleria mellonella.Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells.Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides.Mutations at position 1122 in the catalytic domain of the mouse ras-specific guanine nucleotide exchange factor CDC25Mm originate both loss-of-function and gain-of-function proteins.Deinococcus radiodurans can interfere with quorum sensing by producing an AHL-acylase and an AHL-lactonase.S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1).Altering the substrate specificity of cephalosporin acylase by directed evolution of the Beta -subunit.Structure-function relationships of elongation factor Tu. Isolation and activity of the guanine-nucleotide-binding domain.The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp.Analysis of a substrate specificity switch residue of cephalosporin acylase.Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase.Minimum requirements for specific binding of RNA and coat protein of alfalfa mosaic virus.Characterization of the interaction between human complement protein C4 and a single-chain variable fragment antibody by capillary electrophoresis and surface plasmon resonance.Heterologous production of Escherichia coli penicillin G acylase in Pseudomonas aeruginosa.Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis.Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Robbert Cool
@nl
Robbert H Cool
@en
Robbert H Cool
@es
Robbert H Cool
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type
label
Robbert Cool
@nl
Robbert H Cool
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Robbert H Cool
@es
Robbert H Cool
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R. Cool
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R.H. Cool
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Robbert H Cool
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prefLabel
Robbert Cool
@nl
Robbert H Cool
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Robbert H Cool
@es
Robbert H Cool
@sl
P106
P21
P31
P496
0000-0002-9845-2202
P734
P735
P7449
PRS1338526