Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily.
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CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic dosingIdentification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide eliminationCytochrome P4502C9: an enzyme of major importance in human drug metabolismFrequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoinGenetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolismIdentification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism.Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.Clinical implications of drug interactions with coxibs.Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.Evolution of drug metabolism: hitchhiking the technology bandwagon.Clinical relevance of genetic polymorphisms in the human CYP2C9 gene.Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration.Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration?Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.Cytochrome P450 structure-function: insights from molecular dynamics simulations.In vitro analysis of metabolic predisposition to drug hypersensitivity reactions.Phenytoin disposition and toxicity: role of pharmacogenetic and interethnic factors.Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone.Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism.Homology modeling and substrate binding study of human CYP2C9 enzyme.Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity.CYP2C9 amino acid residues influencing phenytoin turnover and metabolite regio- and stereochemistry.Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin.In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8).Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals.Genetic and environmental risk factors for oral anticoagulant overdose.Determination of the human cytochrome P450s involved in the metabolism of 2n-propylquinoline.Catalytic activities of human cytochrome P450 2C9*1, 2C9*3 and 2C9*13.Pharmacogenomics of CYP2C9: Functional and Clinical Considerations.Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes.Functional characterization of 32 CYP2C9 allelic variants.Mechanism of the decrease in catalytic activity of human cytochrome P450 2C9 polymorphic variants investigated by computational analysis.The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents
P2860
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P2860
Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Site-directed mutation studies ...... nzymes in the CYP2C subfamily.
@en
type
label
Site-directed mutation studies ...... nzymes in the CYP2C subfamily.
@en
prefLabel
Site-directed mutation studies ...... nzymes in the CYP2C subfamily.
@en
P2093
P2860
P356
P1433
P1476
Site-directed mutation studies ...... nzymes in the CYP2C subfamily.
@en
P2093
Birkett DJ
Mackenzie PI
McManus ME
Veronese ME
P2860
P304
P356
10.1042/BJ2890533
P407
P478
289 ( Pt 2)
P577
1993-01-01T00:00:00Z