Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
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Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.A modeling approach to evaluate the balance between bioactivation and detoxification of MeIQx in human hepatocytes.A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.Reduced order modeling and analysis of the human complement system.Prediction of drug-drug interaction potential using physiologically based pharmacokinetic modeling.A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.Challenges Associated with Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making.Highlight report: physiologically-based modeling of diseased liver tissue.Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation.Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situationsPBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin
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Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
@en
type
label
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
@en
prefLabel
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
@en
P2093
P2860
P50
P356
P1476
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
@en
P2093
P2860
P304
P356
10.1002/PSP4.12134
P577
2016-09-21T00:00:00Z