New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis.
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Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side ChainsDrug Metabolism - From In Vitro to In Vivo, From Simple to Complex: Reflections of the BCPT Nordic Prize 2014 AwardeeMolecular characterization of CYP2B6 substratesComputational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanismsPharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevanceThe effect of ritonavir on human CYP2B6 catalytic activity: heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavirQSAR of cytochrome inhibitors.Insights on cytochrome p450 enzymes and inhibitors obtained through QSAR studies.Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes.Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitroIdentification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach.Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences.
P2860
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P2860
New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
New potent and selective cytoc ...... lationship (3D-QSAR) analysis.
@en
type
label
New potent and selective cytoc ...... lationship (3D-QSAR) analysis.
@en
prefLabel
New potent and selective cytoc ...... lationship (3D-QSAR) analysis.
@en
P2093
P2860
P356
P1476
New potent and selective cytoc ...... lationship (3D-QSAR) analysis.
@en
P2093
C Wittekindt
L E Korhonen
M Rahnasto
O Pelkonen
R O Juvonen
P2860
P304
P356
10.1038/SJ.BJP.0707173
P407
P577
2007-02-26T00:00:00Z