Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules.
about
Newly identified pair of proteasomal subunits regulated reciprocally by interferon gammaAssembly, intracellular localization, and nucleotide binding properties of the human peptide transporters TAP1 and TAP2 expressed by recombinant vaccinia virusesExpression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell linesIdentification of human cancers deficient in antigen processingIn vivo assembly of the proteasomal complexes, implications for antigen processingDifferential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type 12-transformed cellsDirect identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells.The requirement for proteasome activity class I major histocompatibility complex antigen presentation is dictated by the length of preprocessed antigen.Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cellsIFN-beta mediates coordinate expression of antigen-processing genes in RSV-infected pulmonary epithelial cells.The specificity of proteasomes: impact on MHC class I processing and presentation of antigens.Proteolysis and class I major histocompatibility complex antigen presentation.A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases.Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2)A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice.Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartmentTargeted delivery of peptide epitopes to class I major histocompatibility molecules by a modified Pseudomonas exotoxin.Restrictions on the use of antigenic peptides by the immune systemComparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing.Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter.LMP-associated proteolytic activities and TAP-dependent peptide transport for class 1 MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12.Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system.The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope.Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide.The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome.Antigen presentation machinery (APM) modulation and soluble HLA molecules in the tumor microenvironment: do they provide tumor cells with escape mechanisms from recognition by cytotoxic T lymphocytes?Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent mannerA ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell cloneMolecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I.Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.Oligomerization of human ATP-binding cassette transporters and its potential significance in human disease.Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3.HLA class I antigen downregulation by interleukin (IL)-10 is predominantly governed by NK-kappaB in the short term and by TAP1+2 in the long term.Induction of heat shock protein gp96 by immune cytokines.
P2860
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P2860
Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Proteasome subunits encoded in ...... ound by MHC class I molecules.
@en
type
label
Proteasome subunits encoded in ...... ound by MHC class I molecules.
@en
prefLabel
Proteasome subunits encoded in ...... ound by MHC class I molecules.
@en
P2093
P356
P1433
P1476
Proteasome subunits encoded in ...... ound by MHC class I molecules.
@en
P2093
P2888
P304
P356
10.1038/360171A0
P407
P577
1992-11-01T00:00:00Z
P6179
1016437140