Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors.
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Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulationsEffect of multiple serine/alanine mutations in the transmembrane spanning region V of the D2 dopamine receptor on ligand bindingInvestigation of D₂ receptor-agonist interactions using a combination of pharmacophore and receptor homology modeling.Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548.Imaging transgene expression with radionuclide imaging technologiesInteraction of novel hybrid compounds with the D3 dopamine receptor: Site-directed mutagenesis and homology modeling studiesDevelopment of 7TM receptor-ligand complex models using ligand-biased, semi-empirical helix-bundle repacking in torsion space: application to the agonist interaction of the human dopamine D2 receptor.Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.Dopamine receptor microdomains involved in molecular recognition and the regulation of drug affinity and function.Receptor conformations involved in dopamine D(2L) receptor functional selectivity induced by selected transmembrane-5 serine mutations.Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency.Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.Modeling and protein engineering studies of active and inactive states of human dopamine D2 receptor (D2R) and investigation of drug/receptor interactions.Critical analysis of the successes and failures of homology models of G protein-coupled receptors.Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction.The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.Role of conserved serine residues in the interaction of agonists with D3 dopamine receptors.Mapping of dopamine D3 receptor binding site by pharmacological characterization of mutants expressed in CHO cells with the Semliki Forest virus system.Expression and characterization of human dopamine D2 receptor in baculovirus-infected insect cells.Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation.Ser203 as well as Ser204 and Ser207 in fifth transmembrane domain of the human beta2-adrenoceptor contributes to agonist binding and receptor activation.Mechanisms of ligand binding and efficacy at the human D2(short) dopamine receptor.Ligand-binding modes in cationic biogenic amine receptors.Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals.Potential usefulness of D2R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases.Cloning and expression of a complementary DNA encoding a molluscan octopamine receptor that couples to chloride channels in HEK293 cells.The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.
P2860
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P2860
Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Contributions of conserved ser ...... ds with dopamine D2 receptors.
@en
type
label
Contributions of conserved ser ...... ds with dopamine D2 receptors.
@en
prefLabel
Contributions of conserved ser ...... ds with dopamine D2 receptors.
@en
P2093
P2860
P1476
Contributions of conserved ser ...... ds with dopamine D2 receptors.
@en
P2093
P2860
P304
P356
10.1111/J.1471-4159.1992.TB09416.X
P407
P577
1992-08-01T00:00:00Z