Characterization of the p33 subunit of eukaryotic translation initiation factor-3 from Saccharomyces cerevisiae.
about
Reconstitution reveals the functional core of mammalian eIF3The translational factor eIF3f: the ambivalent eIF3 subunitA multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivoA 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes.Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding.The RNA recognition motif of eukaryotic translation initiation factor 3g (eIF3g) is required for resumption of scanning of posttermination ribosomes for reinitiation on GCN4 and together with eIF3i stimulates linear scanning.Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast.A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met.The Saccharomyces cerevisiae HCR1 gene encoding a homologue of the p35 subunit of human translation initiation factor 3 (eIF3) is a high copy suppressor of a temperature-sensitive mutation in the Rpg1p subunit of yeast eIF3.Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit.A multifactor complex of eIF1, eIF2, eIF3, eIF5, and tRNA(i)Met promotes initiation complex assembly and couples GTP hydrolysis to AUG recognition.Molecular mechanism of scanning and start codon selection in eukaryotes.The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis.NIa-Pro of Papaya ringspot virus interacts with Carica papaya eukaryotic translation initiation factor 3 subunit G (CpeIF3G).Plant initiation factor 3 subunit composition resembles mammalian initiation factor 3 and has a novel subunit.Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.
P2860
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P2860
Characterization of the p33 subunit of eukaryotic translation initiation factor-3 from Saccharomyces cerevisiae.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Characterization of the p33 su ...... from Saccharomyces cerevisiae.
@en
type
label
Characterization of the p33 su ...... from Saccharomyces cerevisiae.
@en
prefLabel
Characterization of the p33 su ...... from Saccharomyces cerevisiae.
@en
P2093
P2860
P356
P1476
Characterization of the p33 su ...... from Saccharomyces cerevisiae.
@en
P2093
Hershey JW
Vornlocher HP
P2860
P304
P356
10.1074/JBC.274.13.8546
P407
P577
1999-03-01T00:00:00Z