The dynamics of signal triggering in a gp130-receptor complex.
about
Insights into cytokine-receptor interactions from cytokine engineeringAn unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptorStructural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane ComplexConservation of Functional Sites on Interleukin-6 and Implications for Evolution of Signaling Complex Assembly and Therapeutic InterventionThe structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6Leukemia inhibitory factor (LIF)Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexesStructural biology of shared cytokine receptors.More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.gp130: a promising drug target for cancer therapy.IL-11 signaling as a therapeutic target for cancer.Interleukin-11: A Multifunctional Cytokine with Intrinsically Disordered Regions.Non-core region modulates interleukin-11 signaling activity: generation of agonist and antagonist variants.interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration.Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex.Hamiltonian replica exchange combined with elastic network analysis to enhance global domain motions in atomistic molecular dynamics simulations.The length of the interleukin-11 receptor stalk determines its capacity for classic signaling.gp130 activation is regulated by D2-D3 interdomain connectivity.Cytokine Receptors
P2860
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P2860
The dynamics of signal triggering in a gp130-receptor complex.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The dynamics of signal triggering in a gp130-receptor complex.
@en
type
label
The dynamics of signal triggering in a gp130-receptor complex.
@en
prefLabel
The dynamics of signal triggering in a gp130-receptor complex.
@en
P2093
P2860
P1433
P1476
The dynamics of signal triggering in a gp130-receptor complex.
@en
P2093
Rishi Matadeen
Stephen Fuller
Wai-Ching Hon
P2860
P304
P356
10.1016/J.STR.2007.02.006
P577
2007-04-01T00:00:00Z