about
High-dimensional single-cell cancer biologyMelanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocksNetworkPainter: dynamic intracellular pathway animation in Cytobank.Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric dataWebFlow: a software package for high-throughput analysis of flow cytometry dataMitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.The use of fluorescently-tagged apoptolidins in cellular uptake and response studies.B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progressionWeb-based analysis and publication of flow cytometry experiments.Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphomaSingle cell profiling of potentiated phospho-protein networks in cancer cells.Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentationK-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cellsCutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B CellsHigh-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy.High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells.Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry.Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 TherapyAltered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patientsNovel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity.In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment.Characterizing Phenotypes and Signaling Networks of Single Human Cells by Mass Cytometry.Systems immune monitoring in cancer therapy.Characterizing cell subsets using marker enrichment modeling.Regulatory myeloid cells: an underexplored continent in B-cell lymphomas.Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatmentHierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphomaCharacterization of patient specific signaling via augmentation of Bayesian networks with disease and patient state nodes.Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells.Beyond the age of cellular discovery.Mapping normal and cancer cell signalling networks: towards single-cell proteomics.Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations.Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics.Generating Quantitative Cell Identity Labels with Marker Enrichment Modeling (MEM).Single cell analysis of human tissues and solid tumors with mass cytometry.Preparing Viable Single Cells from Human Tissue and Tumors for Cytomic Analysis.Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow.
P50
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P50
description
cell biologist
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hulumtues
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wetenschapper
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հետազոտող
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name
Jonathan M. Irish
@ast
Jonathan M. Irish
@en
Jonathan M. Irish
@es
Jonathan M. Irish
@nl
Jonathan M. Irish
@sl
type
label
Jonathan M. Irish
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Jonathan M. Irish
@en
Jonathan M. Irish
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Jonathan M. Irish
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Jonathan M. Irish
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prefLabel
Jonathan M. Irish
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Jonathan M. Irish
@en
Jonathan M. Irish
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Jonathan M. Irish
@nl
Jonathan M. Irish
@sl
P1053
E-1180-2013
P106
P1153
56254605700
7101847425
P21
P2798
P31
P3829
P496
0000-0001-9428-8866