Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
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HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivoPositive and negative regulation of T-cell activation through kinases and phosphatasesT cell recognition of weak ligands: roles of signaling, receptor number, and affinityProtein tyrosine phosphatases and the immune responseThe protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functionsSHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsPTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.T cell activation and differentiation is modulated by a CD6 domain 1 antibody ItolizumabActivation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cellsA discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits.Role of protein tyrosine phosphatases in T cell activation.Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development.Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivoModulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responsesRegulating naïve and memory CD8 T cell homeostasis--a role for protein tyrosine phosphatases.PD-1 coinhibitory signals: the link between pathogenesis and protection.A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.Treatment of human T cells with bisperoxovanadium phosphotyrosyl phosphatase inhibitors leads to activation of cyclooxygenase-2 gene.Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray.An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function.The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development.Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction.A mathematical analysis of TCR serial triggering and down-regulation.Recruitment of SHP-1 Protein Tyrosine Phosphatase and Signalling by a Chimeric T-Cell Receptor-Killer Inhibitory ReceptorCommentary: Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological SynapseSHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling
P2860
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P2860
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
@en
type
label
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
@en
prefLabel
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
@en
P2093
P2860
P1476
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
@en
P2093
J Brockdorff
S Williams
T Mustelin
P2860
P304
P356
10.1002/(SICI)1521-4141(199908)29:08<2539::AID-IMMU2539>3.0.CO;2-M
P407
P577
1999-08-01T00:00:00Z