Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.
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Transmission of influenza A virusesNovel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza VirusesIdentification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cellsMammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus.Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses.Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human CellsRapid acquisition of polymorphic virulence markers during adaptation of highly pathogenic avian influenza H5N8 virus in the mouseAdditional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice.Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian AdaptationA Single Amino Acid in the M1 Protein Responsible for the Different Pathogenic Potentials of H5N1 Highly Pathogenic Avian Influenza Virus Strains.Dual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease.Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virusPB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesGlycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice.Amino acid changes in PB2 and HA affect the growth of a recombinant influenza virus expressing a fluorescent reporter proteinH5N1 influenza virulence, pathogenicity and transmissibility: what do we know?Altered virulence of Highly Pathogenic Avian Influenza (HPAI) H5N8 reassortant viruses in mammalian models.Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.Enhanced virulence of clade 2.3.2.1 highly pathogenic avian influenza A H5N1 viruses in ferrets.Expected Effect of Deleterious Mutations on Within-Host Adaptation of Pathogens.Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in miceH7N9 virulent mutants detected in chickens in China pose an increased threat to humans.Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence.Characterization of H5N1 influenza virus quasispecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells.Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates
P2860
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P2860
Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.
@en
type
label
Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.
@en
prefLabel
Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.
@en
P2093
P2860
P356
P1476
Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.
@en
P2093
Catherine A Macken
Gabriele Neumann
Jin Hyun Kim
Mai Quynh Le
Masaki Imai
Masato Hatta
Peter Halfmann
Shufang Fan
Tung Nguyen
P2860
P2888
P356
10.1038/NCOMMS6021
P407
P577
2014-10-07T00:00:00Z