Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model - Wikidata - awgldk - TriplyDB

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

http://www.wikidata.org/entity/Q41723730

about

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date.Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts.The role of genetically engineered pigs in xenotransplantation research.Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation.Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors Increase in anti-Gal IgM level is associated with early graft failure in intraportal porcine islet xenotransplantation.In vitro testing of an anti-CD40 monoclonal antibody, clone 2C10, in primates and pigs.Current status of pig heart xenotransplantation.Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models.Xenotransplantation literature update, January-February 2014.Regulation of Clinical Xenotransplantation-Time for a Reappraisal.The pathobiology of pig-to-primate xenotransplantation: a historical review.Progress in Clinical Encapsulated Islet Xenotransplantation.Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys.Molecular immunology profiles of monkeys following xenografting with the islets and heart of α-1,3-galactosyltransferase knockout pigs.Recent advances in understanding xenotransplantation: implications for the clinic.Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?The impact of serum incubation time on IgM/IgG binding to porcine aortic endothelial cells.Transplantation of hepatocytes from genetically engineered pigs into baboons.Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation.Pre-clinical heterotopic intrathoracic heart xenotransplantation: a possibly useful clinical technique.

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P2860

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

http://www.wikidata.org/entity/Q41723730

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Role of anti-CD40 antibody-med ...... KO.hCD46Tg pig-to-baboon model

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Role of anti-CD40 antibody-med ...... KO.hCD46Tg pig-to-baboon model

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Avneesh K Singh

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Billeta G T Lewis

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David Ayares

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Keith A Horvath

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Keith A Reimann

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Marvin L Thomas

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Michael Eckhaus

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Nicole L Dabkowski

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Philip C Corcoran

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Robert F Hoyt

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P2860

Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons

Clinical xenotransplantation of organs: why aren't we there yet?

A novel monoclonal antibody to CD40 prolongs islet allograft survival

Human membrane cofactor protein (MCP, CD 46) protects transgenic pig hearts from hyperacute rejection in primates.

Co-stimulation blockade targeting CD154 and CD28/B7 modulates the induced antibody response after a pig-to-baboon cardiac xenograft.

Overcoming the barriers to xenotransplantation: prospects for the future

Production of alpha 1,3-galactosyltransferase-deficient pigs.

Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model.

B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.

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35-45

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10.1111/XEN.12066

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1

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