A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.
about
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancerThe Novel PKCθ from Benchtop to ClinicUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingComplex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cellsVav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyteCD28 and CTLA-4 coreceptor expression and signal transductionDeciphering the pathway from the TCR to NF-kappaBCD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axisPOLKADOTS are foci of functional interactions in T-Cell receptor-mediated signaling to NF-kappaB.Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cellsProtein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responsesMembrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-thetaSpatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.Morphological change of CD4(+) T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapseMembrane raft association of CD47 is necessary for actin polymerization and protein kinase C theta translocation in its synergistic activation of T cells.Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis.Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivoVav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoterAn enigmatic tail of CD28 signaling.CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.T lymphocyte activation--an inside overview.WASp in immune-system organization and function.The regulation of actin remodeling during T-cell-APC conjugate formation.Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions.The distal pole complex: a novel membrane domain distal to the immunological synapse.Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation.Protein kinase C-theta (PKCtheta): it's all about location, location, location.The PKC gene module: molecular biosystematics to resolve its T cell functions.Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-thetaTransducing signals from antigen receptors to nuclear factor kappaB.Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation.Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer.TEC-family kinases: regulators of T-helper-cell differentiation.
P2860
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P2860
A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
A novel functional interaction ...... TCR-induced T cell activation.
@en
type
label
A novel functional interaction ...... TCR-induced T cell activation.
@en
prefLabel
A novel functional interaction ...... TCR-induced T cell activation.
@en
P2093
P1433
P1476
A novel functional interaction ...... TCR-induced T cell activation
@en
P2093
P304
P356
10.1016/S1074-7613(00)80168-5
P407
P577
2000-02-01T00:00:00Z