Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells.
about
Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinismSomatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cellsGαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells.Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells.Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells.Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteinsBlock of Ca(2+)-channels by alpha-endosulphine inhibits insulin release.Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations.Hyperinsulinism in infancy: from basic science to clinical disease.Ionomycin-induced acetylcholine release and its inhibition by adenosine at frog motor nerve endings.Illuminating somatostatin analog action at neuroendocrine tumor receptorsEffects of glucose, forskolin and tolbutamide on membrane potential and insulin secretion in the insulin-secreting cell line INS-1.Adrenaline-, not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells. Activation of sulphonylurea K+ATP channels is not involved.The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.Dynamics of Ca2+ and guanosine 5'-[gamma-thio]triphosphate action on insulin secretion from alpha-toxin-permeabilized HIT-T15 cells.Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins.Inhibition by somatostatin of amylase secretion induced by calcium and cyclic AMP in rat pancreatic acini.Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.
P2860
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P2860
Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Somatostatin inhibition of Ca2 ...... n permeabilized HIT-T15 cells.
@en
type
label
Somatostatin inhibition of Ca2 ...... n permeabilized HIT-T15 cells.
@en
prefLabel
Somatostatin inhibition of Ca2 ...... n permeabilized HIT-T15 cells.
@en
P2093
P2860
P356
P1433
P1476
Somatostatin inhibition of Ca2 ...... n permeabilized HIT-T15 cells.
@en
P2093
P2860
P304
P356
10.1042/BJ2700273
P407
P577
1990-08-01T00:00:00Z