Characterization and novel purification of recombinant human protein C from three mammalian cell lines.
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Drotrecogin alfa (recombinant human activated protein C) in severe acute pancreatitisActivated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.Functional study of the vitamin K cycle in mammalian cells.Drotrecogin alfa (activated): a novel therapeutic strategy for severe sepsis.Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen.Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylaseDifferential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B.Species-specific anticoagulant and mitogenic activities of murine protein S.Residues 88-109 of factor IXa are important for assembly of the factor X activating complex.Identification of a region in protein C involved in thrombomodulin-stimulated activation by thrombin: potential repulsion at anion-binding site I in thrombinFunctional Study of the Vitamin K Cycle Enzymes in Live Cells.Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications.An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model.The use of engineered E1A genes to transactivate the hCMV-MIE promoter in permanent CHO cell lines.E1a-responsive mammalian host/vector system for the stable high-level expression of secreted proteins.Undercarboxylation of recombinant prothrombin revealed by analysis of gamma-carboxyglutamic acid using capillary electrophoresis and laser-induced fluorescence.Bioproduction of human enzymes in transgenic tobacco.Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency.Recombinant human thrombomodulin. Regulation of cofactor activity and anticoagulant function by a glycosaminoglycan side chainHigh mobility group protein, HMG-1, contains insignificant glycosyl modification.Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.Charge reversal at the P3' position in protein C optimally enhances thrombin affinity and activation rateThe use of prothrombin(S525C) labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation.Glycoengineered factor IX variants with improved pharmacokinetics and subcutaneous efficacy.Identification of functionally important residues of the epidermal growth factor-2 domain of factor IX by alanine-scanning mutagenesis. Residues Asn(89)-Gly(93) are critical for binding factor VIIIa.The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa.The porcine mammary gland as a bioreactor for complex proteins.Rate limitations in posttranslational processing by the mammary gland of transgenic animals.Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity.Choice of cellular protein expression system.Time-course of neopterin levels in patients suffering from severe sepsis treated with and without Drotrecogin-alpha (activated).
P2860
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P2860
Characterization and novel purification of recombinant human protein C from three mammalian cell lines.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Characterization and novel pur ...... om three mammalian cell lines.
@en
type
label
Characterization and novel pur ...... om three mammalian cell lines.
@en
prefLabel
Characterization and novel pur ...... om three mammalian cell lines.
@en
P2093
P2860
P356
P1433
P1476
Characterization and novel pur ...... om three mammalian cell lines.
@en
P2093
Grinnell BW
McClure DB
P2860
P304
P356
10.1038/NBT0790-655
P577
1990-07-01T00:00:00Z