Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
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Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patientsBoth gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancerCancer cell adaptation to chemotherapy.Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of OptionsPharmacologic resistance in colorectal cancer: a reviewThe changing face of chemotherapy in colorectal cancerA polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracilMolecular predictors of survival after adjuvant chemotherapy for colon cancerAntisense-induced down-regulation of thymidylate synthase and enhanced cytotoxicity of 5-FUdR in 5-FUdR-resistant HeLa cellsNuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinomaTumor growth rate determines the timing of optimal chronomodulated treatment schedulesConstitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancerNew insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cellsPhase II trial of S-1 plus leucovorin in patients with advanced gastric cancer and clinical prediction by S-1 pharmacogenetic pathwayMulti-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer.Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification.Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapyEfficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancerThymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine.Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences.The increasing role of pharmacogenetics in the treatment of gastrointestinal cancers.Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cellsThe colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information.The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma.Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancerMolecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.Thymidine phosphorylase gene variant, platelet counts and survival in gastrointestinal cancer patients treated by fluoropyrimidinesAJG series: molecular biology for clinicians.Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 yearsPrognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy.Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorinA predictive factor for the response to S-1 plus cisplatin in gastric cancer.Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis.Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.Impact of dihydropyrimidine dehydrogenase and γ-glutamyl hydrolase on the outcomes of patients treated with gemcitabine or S-1 as adjuvant chemotherapy for advanced pancreatic cancer.Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassayThymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma.Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?STRAP is a strong predictive marker of adjuvant chemotherapy benefit in colorectal cancer.
P2860
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P2860
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Colorectal tumors responding t ...... , and thymidine phosphorylase.
@en
type
label
Colorectal tumors responding t ...... , and thymidine phosphorylase.
@en
prefLabel
Colorectal tumors responding t ...... , and thymidine phosphorylase.
@en
P2093
P1476
Colorectal tumors responding t ...... e, and thymidine phosphorylase
@en
P2093
Danenberg KD
Danenberg PV
Leichman CG
Leichman L
P304
P407
P577
2000-04-01T00:00:00Z