A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.
about
Chemoselectivity in chemical biology: acyl transfer reactions with sulfur and seleniumBioorthogonal chemistry: fishing for selectivity in a sea of functionalityClick chemistry in complex mixtures: bioorthogonal bioconjugationKinugasa reactions in water: from green chemistry to bioorthogonal labellingMechanism-based triarylphosphine-ester probes for capture of endogenous RSNOsAn integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profilingΠ-Clamp-mediated cysteine conjugationCreating site-specific isopeptide linkages between proteins with the traceless Staudinger ligation.Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins.Methodologies for the characterization, identification and quantification of S-nitrosylated proteins.Chemical and semisynthesis of posttranslationally modified proteins.Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.Strain-promoted sydnone bicyclo-[6.1.0]-nonyne cycloaddition†Electronic supplementary information (ESI) available: Full experimental details, (1)H/(13)C NMR spectral data, protein synthesis and purification. See DOI: 10.1039/c3sc53332h.4R- and 4S-iodophenyl hydroxyproline, 4R-pentynoyl hydroxyproline, and S-propargyl-4-thiolphenylalanine: conformationally biased and tunable amino acids for bioorthogonal reactions.Direct screening of solution phase combinatorial libraries encoded with externally sensitized photolabile tags.Protein damage by reactive electrophiles: targets and consequencesTyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry.Chemoenzymatic site-specific reversible immobilization and labeling of proteins from crude cellular extract without prior purification using oxime and hydrazine ligationChemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid-hydroxylamine (KAHA) ligationSynthesis of chemically modified bioactive peptides: recent advances, challenges and developments for medicinal chemistry.Biomolecular surface engineering of pancreatic islets with thrombomodulin.Long-term survival of allograft murine islets coated via covalently stabilized polymers.His6 tag-assisted chemical protein synthesisBioorthogonal chemistry: recent progress and future directions.Bioorthogonal Chemistry-A Covalent Strategy for the Study of Biological Systems.Challenges for protein chemical synthesis in the 21st century: bridging genomics and proteomics.Fast hydrazone reactants: electronic and acid/base effects strongly influence rate at biological pH.AMIDE FORMATION BY DECARBOXYLATIVE CONDENSATION OF HYDROXYLAMINES AND α-KETOACIDS: N-[(1S)-1 PHENYLETHYL]-BENZENEACETAMIDE.A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animalsMethods and strategies of peptide ligation.In situ click chemistry: a powerful means for lead discovery.Radioiodinated O(6)-Benzylguanine derivatives containing an azido function.Fluorine-18 radiochemistry, labeling strategies and synthetic routesSelective enrichment and identification of azide-tagged cross-linked peptides using chemical ligation and mass spectrometry.N,N-diethylurea-catalyzed amidation between electron-deficient aryl azides and phenylacetaldehydes.Protein microarrays: novel developments and applications.From mechanism to mouse: a tale of two bioorthogonal reactionsChemical and biological properties of polymer-modified proteins.Click chemistry patents and their impact on drug discovery and chemical biology.Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18O-labeling.
P2860
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P2860
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.
@en
type
label
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.
@en
prefLabel
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.
@en
P2093
P356
P1433
P1476
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.
@en
P2093
Armstrong JI
Bertozzi CR
P304
P356
10.1021/OL006054V
P407
P577
2000-07-01T00:00:00Z