Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells.
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Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition.A conceptual mathematical model of the dynamic self-organisation of distinct cellular organellesAcute doxorubicin insult in the mouse ovary is cell- and follicle-type dependentChemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expressionMolecular Determinants of GS-9620-Dependent TLR7 ActivationEnhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration.Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs.Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition.The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors.Multistage nanoparticle delivery system for deep penetration into tumor tissue.Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy.Sequestration of AS-DACA into acidic compartments of the membrane trafficking system as a mechanism of drug resistance in rhabdomyosarcomaRole of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191.Naphthalene diimides as red fluorescent pH sensors for functional cell imaging.Polymer genomics: an insight into pharmacology and toxicology of nanomedicinesIdentification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma.Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cellsTumor acidity, chemoresistance and proton pump inhibitors.Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient: pluronic P85.The Function of V-ATPases in CancerDaunomycin, an antitumor DNA intercalator, influences histone-DNA interactions.Toward a new age of cellular pharmacokinetics in drug discovery.Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications.Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance.Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer.Resistance mechanisms of cancer cells to the novel vacuolar H(+)-ATPase inhibitor archazolid B.LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.Photoswitchable nanoparticles for triggered tissue penetration and drug delivery.Isolation and characterization of squamous carcinoma cells resistant to photodynamic therapy.Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe.Tumor microenvironment interruption: a novel anti-cancer mechanism of Proton-pump inhibitor in gastric cancer by suppressing the release of microRNA-carrying exosomes.Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine in murine models.Proton pump inhibitors may reduce tumour resistance.Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin
P2860
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P2860
Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Inhibitors of vacuolar H+-ATPa ...... istant renal epithelial cells.
@en
type
label
Inhibitors of vacuolar H+-ATPa ...... istant renal epithelial cells.
@en
prefLabel
Inhibitors of vacuolar H+-ATPa ...... istant renal epithelial cells.
@en
P2093
P2860
P356
P1433
P1476
Inhibitors of vacuolar H+-ATPa ...... sistant renal epithelial cells
@en
P2093
Alain Vandewalle
Caroline Vignes
Claudine Pringel
Francçoise Cluzeaud
Jocelyne Fleury
Marcelle Bens
Roger Lacave
Zahia Ouar
P2860
P304
P356
10.1042/BJ20021411
P407
P50
P577
2003-02-01T00:00:00Z