Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.
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Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseBiophysical Aspects of T Lymphocyte Activation at the Immune SynapseLower Affinity T Cells are Critical Components and Active Participants of the Immune ResponseStructural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discriminationαβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapyIndoctrinating T cells to attack pathogens through homeschoolingNanoscale optomechanical actuators for controlling mechanotransduction in living cellsStructural Model of the Extracellular Assembly of the TCR-CD3 Complex.Catch-bond mechanism of the bacterial adhesin FimH.The advantages of PD1 activating chimeric receptor (PD1-ACR) engineered lymphocytes for PDL1(+) cancer therapyForce-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flowMechanical regulation of calcium signaling of HL-60 on P-selectin under flowT cell activation requires force generationA generalizable, tunable microfluidic platform for delivering fast temporally varying chemical signals to probe single-cell response dynamics.DNA-based digital tension probes reveal integrin forces during early cell adhesion.F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity.L-selectin mechanochemistry restricts neutrophil priming in vivo.Simultaneous impedance spectroscopy and fluorescence microscopy for the real-time monitoring of the response of cells to drugs.Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.Molecular architecture of the αβ T cell receptor-CD3 complex.Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobilityUse of TIRF to Monitor T-Lymphocyte Membrane Dynamics with Submicrometer and Subsecond Resolution.Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation.Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar AntigensDistortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideA Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold.Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.Backbone resonance assignment of N15, N30 and D10 T cell receptor β subunits.Revealing the TCR bias for MHC moleculesCytotoxic T Cells Use Mechanical Force to Potentiate Target Cell KillingTapping out a mechanical code for T cell triggeringCooperative unfolding of distinctive mechanoreceptor domains transduces force into signals.Functional role of T-cell receptor nanoclusters in signal initiation and antigen discriminationA model for cyclic mechanical reinforcement.A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.Insights into the initiation of TCR signaling.
P2860
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P2860
Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Accumulation of dynamic catch ...... MHC triggers T cell signaling.
@en
type
label
Accumulation of dynamic catch ...... MHC triggers T cell signaling.
@en
prefLabel
Accumulation of dynamic catch ...... MHC triggers T cell signaling.
@en
P2860
P1433
P1476
Accumulation of dynamic catch ...... -MHC triggers T cell signaling
@en
P2093
P2860
P304
P356
10.1016/J.CELL.2014.02.053
P407
P577
2014-04-01T00:00:00Z