Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. - Wikidata - awgldk - TriplyDB

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.

http://www.wikidata.org/entity/Q41770674

about

Inflammasome/IL-1β Responses to Streptococcal Pathogens Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination Reactive oxygen species at the crossroads of inflammasome and inflammation Insights into phagocytosis-coupled activation of pattern recognition receptors and inflammasomes Mechanisms of inflammasome activation: recent advances and novel insights Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production Neutrophils: Between host defence, immune modulation, and tissue injury Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst Localization and functionality of the inflammasome in neutrophils Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death.Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis.Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome.Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma.Intravascular immunity as a key to systemic vasculitis: a work in progress, gaining momentum.Caspase-1/ASC inflammasome-mediated activation of IL-1β-ROS-NF-κB pathway for control of Trypanosoma cruzi replication and survival is dispensable in NLRP3-/- macrophages.Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters.Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular.Staphylococcus aureus Strain USA300 Perturbs Acquisition of Lysosomal Enzymes and Requires Phagosomal Acidification for Survival inside Macrophages.The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production.Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance.Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling.Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance Differential roles of caspase-1 and caspase-11 in infection and inflammation.The signaling pathway of NADPH oxidase and its role in glomerular diseases.Caspases as the key effectors of inflammatory responses against bacterial infection.Scaling of immune responses against intracellular bacterial infection.Perception of self: distinguishing autoimmunity from autoinflammation.An In Vitro Model for the Study of the Macrophage Response Upon Trichophyton rubrum Challenge.Inflammasome Complexes: Emerging Mechanisms and Effector Functions.Alternative functions for the multifarious inflammasome.Necroptosis induced by RIPK3 requires MLKL but not Drp1.Inflammasomes and intestinal inflammation.Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles).

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P2860

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.

http://www.wikidata.org/entity/Q41770674

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Activation of caspase-1 by the ...... to control phagosome function.

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Nature Immunology

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Activation of caspase-1 by the ...... to control phagosome function.

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P2093

Anna Sokolovska

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Antoine Tanne

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Christine E Becker

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Katherine A Fitzgerald

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Lynda M Stuart

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Matthew Brudner

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Nicholas Paquette

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Sivapriya K Vanaja

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Vijay A K Rathinam

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W K Eddie Ip

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P2860

Active caspase-1 is a regulator of unconventional protein secretion

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini

A role for mitochondria in NLRP3 inflammasome activation

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

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543-553

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10.1038/NI.2595

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6

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14

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Adam Lacy-Hulbert

Kathryn J Moore

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2013-05-05T00:00:00Z

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236638541

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23644505

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3708594

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