Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow.
about
Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancerKrit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesionA LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and plateletsLeukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory diseaseMoving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytesRas family of small GTPases in immunity and inflammationEzrin and moesin are required for efficient T cell adhesion and homing to lymphoid organsThe direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged.Effect of adhesion and chemokine presentation on T-lymphocyte haptokinesis.Statin therapy and autoimmune disease: from protein prenylation to immunomodulationRap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrestTyrosine kinases EnAbling adaptor molecules for chemokine-induced Rap1 activation in T cellsStructural basis of integrin regulation and signalingMHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo.Leukocyte migration and graft-versus-host disease.The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration.RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegansMst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions.Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila.The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edgeRadil controls neutrophil adhesion and motility through β2-integrin activation.Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1Optogenetic control of chemokine receptor signal and T-cell migration.The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.CRK proteins selectively regulate T cell migration into inflamed tissues.Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells.Neutrophil adhesion and activation under flow.Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells.Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activationContribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.Activation of Rap1 promotes prostate cancer metastasisCrucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking.Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells.
P2860
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P2860
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Rap1 translates chemokine sign ...... scular endothelium under flow.
@en
type
label
Rap1 translates chemokine sign ...... scular endothelium under flow.
@en
prefLabel
Rap1 translates chemokine sign ...... scular endothelium under flow.
@en
P2093
P2860
P356
P1476
Rap1 translates chemokine sign ...... scular endothelium under flow.
@en
P2093
Koko Katagiri
Mika Shimonaka
Naoya Fujita
Osamu Yoshie
Takashi Tsuruo
Tatsuo Kinashi
P2860
P304
P356
10.1083/JCB.200301133
P407
P577
2003-04-21T00:00:00Z