about
Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNaseTargeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's diseaseChemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synucleinSolution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregationProbing small molecule binding to amyloid fibrils.Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregationRelationship between prion propensity and the rates of individual molecular steps of fibril assembly.Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongationQuantitative thermophoretic study of disease-related protein aggregatesInfluence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence.Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy.Biosensor-based label-free assays of amyloid growth.The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.The Nucleation of Protein Aggregates - From Crystals to Amyloid Fibrils.Protein microgels from amyloid fibril networks.Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.Electrostatic effects in filamentous protein aggregation.Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.The length distribution of frangible biofilaments.Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.Nanostructured films from hierarchical self-assembly of amyloidogenic proteins.Population of nonnative states of lysozyme variants drives amyloid fibril formation.Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways.Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors.β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth.Surface attachment of protein fibrils via covalent modification strategies.Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis.Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.Position-dependent electrostatic protection against protein aggregation.Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform.Acceleration of α-synuclein aggregation.Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alexander K Buell
@ast
Alexander K Buell
@en
Alexander K Buell
@es
Alexander K Buell
@nl
type
label
Alexander K Buell
@ast
Alexander K Buell
@en
Alexander K Buell
@es
Alexander K Buell
@nl
prefLabel
Alexander K Buell
@ast
Alexander K Buell
@en
Alexander K Buell
@es
Alexander K Buell
@nl
P1053
B-4155-2013
P106
P21
P31
P3829
P496
0000-0003-1161-3622