D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma - Wikidata - awgldk - TriplyDB

D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma

D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma

http://www.wikidata.org/entity/Q41791057

about

Genetics and Epigenetics of Glioblastoma: Applications and Overall Incidence of IDH1 Mutation New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma Metabolic consequences of oncogenic IDH mutations Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique.Decreased expression of IDH1-R132H correlates with poor survival in gastrointestinal cancer.Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome.Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas.Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.Biological Significance of Mutant Isocitrate Dehydrogenase 1 and 2 in Gliomagenesis.Metabolomic comparison between cells over-expressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism.Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma.Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1.Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients.Isocitrate dehydrogenase 1 mutation subtypes at site 132 and their translational potential in glioma.IDH1 Mutation and World Health Organization 2016 Diagnostic Criteria for Adult Diffuse Gliomas: Advances in Surgical Strategy.Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry.IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.

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D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma

http://www.wikidata.org/entity/Q41791057

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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name

D-2-Hydroxyglutarate producing ...... se 1 mutations found in glioma

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D-2-Hydroxyglutarate producing ...... se 1 mutations found in glioma

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D-2-Hydroxyglutarate producing ...... se 1 mutations found in glioma

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Acta neuropathologica communications

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D-2-Hydroxyglutarate producing ...... se 1 mutations found in glioma

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Ann-Christin Beck

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Johanna-Marie Lehmler

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Jörg Balss

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Leonille Schweizer

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Susanne Weissert

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P2860

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

IDH1 and IDH2 mutations in gliomas

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma.

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours.

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19

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scholarly article

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10.1186/2051-5960-2-19

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2

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Andreas von Deimling

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2014-02-14T00:00:00Z

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260217595

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1032667888

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24529257

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3937031

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