mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
about
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognitionAMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunityThe Mucosal Immune System and Its Regulation by AutophagyAnticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effectInteractions between Autophagy and Inhibitory CytokinesCullin-RING ligases in regulation of autophagyAdvances in Autophagy Regulatory MechanismsSirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular EffectsCrosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac DiseasesAutophagy signal transduction by ATG proteins: from hierarchies to networksAutophagy-Related Deubiquitinating Enzymes Involved in Health and DiseaseTherapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shiftAutophagy in malignant transformation and cancer progressionRUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagyThe ubiquitin system: a critical regulator of innate immunity and pathogen-host interactionsTherapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseasesmTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingDifferential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagyModulation of inflammation by autophagy: Consequences for human diseaseATG16L1: A multifunctional susceptibility factor in Crohn diseasemTOR: a potential therapeutic target in osteoarthritis?Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagyInhibition of mTOR signaling reduces PELP1-mediated tumor growth and therapy resistanceImmunologic manifestations of autophagyA cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologiesFisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factorsIRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial DefensePlacental Origins of Chronic Disease.(Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose.New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeuticsPost-translationally-modified structures in the autophagy machinery: an integrative perspective.Chaperone-like protein p32 regulates ULK1 stability and autophagyAutophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.Autophagy, Endoplasmic Reticulum Stress and the Unfolded Protein Response in Intracerebral Hemorrhage.ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagyLinking adiponectin and autophagy in the regulation of breast cancer metastasis.
P2860
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P2860
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
mTOR inhibits autophagy by con ...... tion through AMBRA1 and TRAF6.
@en
type
label
mTOR inhibits autophagy by con ...... tion through AMBRA1 and TRAF6.
@en
prefLabel
mTOR inhibits autophagy by con ...... tion through AMBRA1 and TRAF6.
@en
P50
P921
P356
P1433
P1476
mTOR inhibits autophagy by con ...... tion through AMBRA1 and TRAF6.
@en
P2093
Christine Gretzmeier
Mauro Piacentini
P2888
P304
P356
10.1038/NCB2708
P50
P577
2013-03-24T00:00:00Z