ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein.
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Versican G3 domain regulates neurite growth and synaptic transmission of hippocampal neurons by activation of epidermal growth factor receptorDiscordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brainADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis.Isolation and purification of versican and analysis of versican proteolysis.ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfateRegulation of thrombospondin1 by extracellular proteases.Age-related differences in human skin proteoglycans.ADAMTS proteoglycanases in the physiological and pathological central nervous systemNeuronally produced versican V2 renders C-fiber nociceptors IB4 -positiveChanges of large molecular weight hyaluronan and versican in the mouse pubic symphysis through pregnancy.Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis.Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae.The basic science of tendinopathy.Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican.Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment.ADAMTS expression and function in central nervous system injury and disorders.The biological role and regulation of versican levels in cancer.BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion.Expression of versican and ADAMTS1, 4, and 5 during bone development in the rat mandible and hind limb.Down-regulated genes in mouse dental papillae and pulp.The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process.Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5.The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.Proteolytic cleavage of versican during cardiac cushion morphogenesis.ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function.Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter.Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.Versican: a novel modulator of hepatic fibrosis.Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury.Versican V0 and V1 guide migratory neural crest cells.
P2860
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P2860
ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
ADAMTS4 (aggrecanase-1) cleave ...... l hyaluronate binding protein.
@en
type
label
ADAMTS4 (aggrecanase-1) cleave ...... l hyaluronate binding protein.
@en
prefLabel
ADAMTS4 (aggrecanase-1) cleave ...... l hyaluronate binding protein.
@en
P2093
P2860
P356
P1433
P1476
ADAMTS4 (aggrecanase-1) cleave ...... l hyaluronate binding protein.
@en
P2093
Amber Cockburn
Dieter R Zimmermann
George Perides
Jennifer Westling
John D Sandy
Paul E Gottschall
Vivian P Thompson
P2860
P304
P356
10.1042/BJ20030896
P407
P577
2004-02-01T00:00:00Z