about
Targeting the Checkpoint to Kill Cancer CellsGain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpointATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.Polo-like kinase 1 inhibits DNA damage response during mitosis.Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA ReplicationOvercoming Treatment Toxicity through Sequential Therapy
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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type
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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Jan Benada
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P21
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0000-0001-5863-0513