Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.
about
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionTPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.Two-pore channels function in calcium regulation in sea star oocytes and embryos.Lysosome and calcium dysregulation in Alzheimer's disease: partners in crimeRegulation of lysosomal ion homeostasis by channels and transportersTwo-pore channels at the intersection of endolysosomal membrane trafficThe GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsTPC: the NAADP discovery channel?Two-pore channels (TPCs): current controversiesConvergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinasesTeaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approachesTwo-Pore Channels and Parkinson's Disease: Where's the Link?Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagic flux and regulation of an interleukin-1β producing inflammasome.Function and dysfunction of two-pore channels.Two-Pore Channels: Lessons from Mutant Mouse ModelsTwo-Pore Channels: Catalyzers of Endolysosomal Transport and Function.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.Autophagy regulates UBC9 levels during viral-mediated tumorigenesis.Acidic Ca2+ stores in neurodegeneration.Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification.TPC2 controls pigmentation by regulating melanosome pH and sizeTwo-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.Glutamate induces autophagy via the two-pore channels in neural cells.Ca(2+) signals, NAADP and two-pore channels: role in cellular differentiation.Ion transport in pigmentation.ITPRs/inositol 1,4,5-trisphosphate receptors in autophagy: From enemy to ally.NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy.Poring over two-pore channel pore mutants.Modulation of Autophagy by Calcium Signalosome in Human Disease.NAD and the aging process: Role in life, death and everything in between.Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy.TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer.Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition.Live-cell Microscopy and Fluorescence-based Measurement of Luminal pH in Intracellular Organelles.
P2860
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P2860
Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Two pore channel 2 (TPC2) inhi ...... by alkalinizing lysosomal pH.
@en
type
label
Two pore channel 2 (TPC2) inhi ...... by alkalinizing lysosomal pH.
@en
prefLabel
Two pore channel 2 (TPC2) inhi ...... by alkalinizing lysosomal pH.
@en
P2093
P2860
P356
P1476
Two pore channel 2 (TPC2) inhi ...... n by alkalinizing lysosomal pH
@en
P2093
Bai-Xia Hao
Connie W M Wong
Richard Graeff
Wu-Tian Wu
Yingying Lu
P2860
P304
24247-24263
P356
10.1074/JBC.M113.484253
P407
P50
P577
2013-07-08T00:00:00Z