The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

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Exploring new routes for secretory protein export from the trans-Golgi network.

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Q49571272-4A4A714B-13BC-410C-96ED-F2C5DA2D88E5

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The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

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http://www.wikidata.org/entity/Q41821018

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2017 nî lūn-bûn

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2017年の論文

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@yue

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The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

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label

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

@en

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The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

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P1476

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

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Christopher B Newgard

http://www.w3.org/2001/XMLSchema#string

Masato Sadahiro

http://www.w3.org/2001/XMLSchema#string

Wei-Jye Lin

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Signals and pools underlying biphasic insulin secretion.

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.

Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance

VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity

Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells

Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A

VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.

Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor.

Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure

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2480-2489

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scholarly article

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10.1016/J.CELREP.2017.08.050

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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C Jiang

Stephen R Salton

Robert J Perz-Edwards

Samuel B Stephens

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2017-09-01T00:00:00Z

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28877479

http://www.w3.org/2001/XMLSchema#string

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5624795

http://www.w3.org/2001/XMLSchema#string

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

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The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

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P1476

P2093

P2860

P304

P31

P356

P433

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P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932