Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy. - Wikidata - awgldk - TriplyDB

Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.

Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.

http://www.wikidata.org/entity/Q41821755

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Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium Is there treatment for Leber hereditary optic neuropathy?Developments in Ocular Genetics: 2013 Annual Review The optic nerve: a "mito-window" on mitochondrial neurodegeneration Vector platforms for gene therapy of inherited retinopathies.Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(-/-) mouse Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases.Let There Be Light: Gene and Cell Therapy for Blindness.Emerging therapies for mitochondrial disorders.NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS.Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results.Gene therapies for inherited retinal disorders.Emerging aspects of treatment in mitochondrial disorders.Leber Hereditary Optic Neuropathy: Bringing the Lab to the Clinic.Therapeutic strategies for Leber's hereditary optic neuropathy: A current update.Leber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways.A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy.Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier.Leber Hereditary Optic Neuropathy: Exemplar of an mtDNA Disease.Toward an elucidation of the molecular genetics of inherited retinal degenerations.

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P2860

Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.

http://www.wikidata.org/entity/Q41821755

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Intravitreal delivery of AAV-N ...... r hereditary optic neuropathy.

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Arpad Palfi

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G Jane Farrar

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Paul F Kenna

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Peter Humphries

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P2860

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells

Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration

Safety and efficacy of gene transfer for Leber's congenital amaurosis

No immune responses by the expression of the yeast Ndi1 protein in rats

Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model

Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function

Effect of gene therapy on visual function in Leber's congenital amaurosis

Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years.

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