Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.
about
DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge.Inhibitors of Protein Methyltransferases and Demethylases.Preclinical Pharmacokinetics and Pharmacodynamics of Pinometostat (EPZ-5676), a First-in-Class, Small Molecule S-Adenosyl Methionine Competitive Inhibitor of DOT1L.Recent progress in developing selective inhibitors of protein methyltransferases.Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches.Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
P2860
Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Optimization of a Fragment-Bas ...... in an Induced Binding Pocket.
@en
type
label
Optimization of a Fragment-Bas ...... in an Induced Binding Pocket.
@en
prefLabel
Optimization of a Fragment-Bas ...... in an Induced Binding Pocket.
@en
P2093
P2860
P1476
Optimization of a Fragment-Bas ...... in an Induced Binding Pocket.
@en
P2093
Christian Ragot
Christoph Gaul
César Fernández
Frédéric Stauffer
Henrik Möbitz
Kim S Beyer
Ralph Tiedt
P2860
P304
P356
10.1021/ACSMEDCHEMLETT.6B00168
P577
2016-06-06T00:00:00Z