Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effectsBiochanin A, a naturally occurring inhibitor of fatty acid amide hydrolasePotential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodentsLack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitroInactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoidsStructure-guided inhibitor design for human FAAH by interspecies active site conversionDiscovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory PainCrystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme InactivationA Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide HydrolaseThe structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymesDual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain ManagementFull Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in MiceFatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disordersLatest advances in the discovery of fatty acid amide hydrolase inhibitorsEnzymatic pathways that regulate endocannabinoid signaling in the nervous systemInhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofenThe inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammationA chemical genetic screen uncovers a small molecule enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in ArabidopsisThe neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system.Interactions of Cannabinoids With Biochemical SubstratesRegulation of inflammatory pain by inhibition of fatty acid amide hydrolase.Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory painThe modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides.Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays.A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive EffectsThe endocannabinoid system and painInhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.The contribution of cyclooxygenase-2 to endocannabinoid metabolism and actionInhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids.Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal greyFatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context.Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis studyThe fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice.The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids.The endocannabinoid system: current pharmacological research and therapeutic possibilities.
P2860
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P2860
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Inhibitors of fatty acid amide ...... ment of cannabinoid receptors.
@en
type
label
Inhibitors of fatty acid amide ...... ment of cannabinoid receptors.
@en
prefLabel
Inhibitors of fatty acid amide ...... ment of cannabinoid receptors.
@en
P2093
P2860
P921
P356
P1476
Inhibitors of fatty acid amide ...... ment of cannabinoid receptors.
@en
P2093
Barbara Costa
Christopher J Fowler
Francesca Comelli
Sandra Holt
P2860
P304
P356
10.1038/SJ.BJP.0706348
P407
P577
2005-10-01T00:00:00Z