Reduced P2x(2) receptor-mediated regulation of endocochlear potential in the ageing mouse cochlea
about
Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing.Hearing loss caused by a P2RX2 mutation identified in a MELAS family with a coexisting mitochondrial 3243AG mutation.ATP activates P2X receptors to mediate gap junctional coupling in the cochlea.ATP-gated ion channels mediate adaptation to elevated sound levels.Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes.Expression and function of pannexins in the inner ear and hearing.Gene expression profiles of the cochlea and vestibular endorgans: localization and function of genes causing deafness.Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System.P2X2 Dominant Deafness Mutations Have No Negative Effect on Wild-Type Isoform: Implications for Functional Rescue and in Deafness Mechanism.
P2860
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P2860
Reduced P2x(2) receptor-mediated regulation of endocochlear potential in the ageing mouse cochlea
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Reduced P2x(2) receptor-mediat ...... al in the ageing mouse cochlea
@en
type
label
Reduced P2x(2) receptor-mediat ...... al in the ageing mouse cochlea
@en
prefLabel
Reduced P2x(2) receptor-mediat ...... al in the ageing mouse cochlea
@en
P2093
P2860
P1476
Reduced P2x(2) receptor-mediat ...... al in the ageing mouse cochlea
@en
P2093
David J B Munoz
Gary D Housley
Peter R Thorne
Ravindra S Telang
Srdjan M Vlajkovic
Vinthiya Paramananthasivam
P2860
P2888
P304
P356
10.1007/S11302-010-9195-6
P577
2010-06-01T00:00:00Z