A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
about
Addressing the challenges of low clearance in drug researchDevelopment of a pneumatically driven active cover lid for multi-well microplates for use in perfusion three-dimensional cell cultureAdvances in Engineered Liver Models for Investigating Drug-Induced Liver InjuryIntegrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochipAccelerating drug discovery via organs-on-chips.Advances in microfluidic materials, functions, integration, and applications.How multi-organ microdevices can help foster drug developmentBioreactor technologies to support liver function in vitro.In vitro platforms for evaluating liver toxicity.Opportunities and limits of cell-based assay miniaturization in drug discovery.Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling.Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.A microphysiological system model of therapy for liver micrometastasesOrganotypic liver culture models: meeting current challenges in toxicity testing.In vitro models for liver toxicity testing.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.Physiologically based pharmacokinetic models: integration of in silico approaches with micro cell culture analogues.Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates.Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis.Microfluidic platforms for hepatocyte cell culture: new technologies and applications.The current status of alternatives to animal testing and predictive toxicology methods using liver microfluidic biochips.Cell and tissue engineering for liver disease.Competency of different cell models to predict human hepatotoxic drugs.Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications.Organ-on-a-chip: development and clinical prospects toward toxicity assessment with an emphasis on bone marrow.The application of engineered liver tissues for novel drug discovery.3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip.Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function.Investigation of acetaminophen toxicity in HepG2/C3a microscale cultures using a system biology model of glutathione depletion.Liver metastases: Microenvironments and ex-vivo models.Engineered Liver Platforms for Different Phases of Drug Development.Liver Cell Culture Devices.Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro.Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems.Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells.Organ-on-a-chip devices advance to market.Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip.Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.Improvement of HepG2/C3a cell functions in a microfluidic biochip.
P2860
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P2860
A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
@en
type
label
A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
@en
prefLabel
A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
@en
P2093
P2860
P1476
A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
@en
P2093
Eric Novik
Martin L Yarmush
Piyun Chao
Timothy J Maguire
P2860
P304
P356
10.1016/J.BCP.2009.11.010
P407
P577
2009-11-27T00:00:00Z