Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection
about
Developing Combined HIV Vaccine Strategies for a Functional CureInnate and Adaptive Immune Regulation During Chronic Viral InfectionsImmune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infectionEarly skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progressionProgrammed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cellsRole of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic optionsMagnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection.Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation.PD-1 coinhibitory signals: the link between pathogenesis and protection.Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection.High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection.Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand.Kill: boosting HIV-specific immune responses.Cell-based flow cytometry assay to measure cytotoxic activity.Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections.Exploiting immune cell metabolic machinery for functional HIV cure and the prevention of inflammaging.Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained.
P2860
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P2860
Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Profound metabolic, functional ...... mary and chronic HIV infection
@en
type
label
Profound metabolic, functional ...... mary and chronic HIV infection
@en
prefLabel
Profound metabolic, functional ...... mary and chronic HIV infection
@en
P2093
P2860
P50
P1433
P1476
Profound metabolic, functional ...... mary and chronic HIV infection
@en
P2093
Elias K Haddad
Florentin-Martial Mbitikon-Kobo
Francesco Andrea Procopio
Jean-Philippe Goulet
Jean-Pierre Routy
Julien Van Grevenynghe
Mohamad Rachid Boulassel
Yoav Peretz
P2860
P304
P356
10.1182/BLOOD-2012-04-422550
P407
P577
2012-09-06T00:00:00Z