Mechanistic pharmacokinetic/target engagement/pharmacodynamic (PK/TE/PD) modeling in deciphering interplay between a monoclonal antibody and its soluble target in cynomolgus monkeys.

Mechanistic pharmacokinetic/target engagement/pharmacodynamic (PK/TE/PD) modeling in deciphering interplay between a monoclonal antibody and its soluble target in cynomolgus monkeys.

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http://www.wikidata.org/entity/Q41867620
Predicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey.The development of therapeutic monoclonal antibodies: overview of the nonclinical safety assessment.Utility of free and total target measurements as target engagement and efficacy biomarkers in biotherapeutic development--opportunities and challenges.Tools for predicting the PK/PD of therapeutic proteins.Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.Impact of Shed/Soluble targets on the PK/PD of approved therapeutic monoclonal antibodies.Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.Interrelationships between Infliximab and Recombinant Tumor Necrosis Factor-α in Plasma Using Minimal Physiologically Based Pharmacokinetic Models.Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model.Orthogonal tools to help determine the required selectivity of ligand-binding assays in drug development.Dose selection of siltuximab for multicentric Castleman's disease.Minimal physiologically-based pharmacokinetic (mPBPK) model for a monoclonal antibody against interleukin-6 in mice with collagen-induced arthritis.
P2860

Mechanistic pharmacokinetic/target engagement/pharmacodynamic (PK/TE/PD) modeling in deciphering interplay between a monoclonal antibody and its soluble target in cynomolgus monkeys.

Item
http://www.wikidata.org/entity/Q41867620
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Mechanistic pharmacokinetic/ta ...... target in cynomolgus monkeys.
@en
type
label
Mechanistic pharmacokinetic/ta ...... target in cynomolgus monkeys.
@en
prefLabel
Mechanistic pharmacokinetic/ta ...... target in cynomolgus monkeys.
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P577
P6179
P698
P932
P356
P1433
P1476
Mechanistic pharmacokinetic/ta ...... target in cynomolgus monkeys.
@en
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P577
P6179
P698
P932