Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation.
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Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channelsThe Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearingStructural Basis for the Differential Effects of CaBP1 and Calmodulin on CaV1.2 Calcium-Dependent InactivationFunctional characterization of CaVα2δ mutations associated with sudden cardiac deathThe multifunctional PE_PGRS11 protein from Mycobacterium tuberculosis plays a role in regulating resistance to oxidative stressCaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylationSTAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triadsThe ß subunit of voltage-gated Ca2+ channelsFunctional dissection of the intramolecular Src homology 3-guanylate kinase domain coupling in voltage-gated Ca2+ channel beta-subunits.NeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation.Emerging evidence for specific neuronal functions of auxiliary calcium channel α₂δ subunits.Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interactionFeatures of a twin-arginine signal peptide required for recognition by a Tat proofreading chaperone.Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV FunctionRigorous assessment and integration of the sequence and structure based features to predict hot spots.The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motif.Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currentsThe guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating.Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation.Structure and function of the β subunit of voltage-gated Ca²⁺ channels.The role of auxiliary subunits for the functional diversity of voltage-gated calcium channels.Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in Ca(V)1.2 channel regulation.A quartet of leucine residues in the guanylate kinase domain of CaVβ determines the plasma membrane density of the CaV2.3 channel.Mutations of nonconserved residues within the calcium channel alpha1-interaction domain inhibit beta-subunit potentiation.Single-channel monitoring of reversible L-type Ca(2+) channel Ca(V)α(1)-Ca(V)β subunit interaction.Negatively charged residues in the first extracellular loop of the L-type CaV1.2 channel anchor the interaction with the CaVα2δ1 auxiliary subunit.Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel.Stable incorporation versus dynamic exchange of β subunits in a native Ca2+ channel complex.Rationalization and prediction of drug resistant mutations in targets for clinical anti-tubercular drugs.Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels.Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner.Distinct functional domains of PNMA5 mediate protein-protein interaction, nuclear localization, and apoptosis signaling in human cancer cells.Inherited Ventricular Arrhythmias: The Role of the Multi-Subunit Structure of the L-Type Calcium Channel Complex.
P2860
Q26864613-93BBDEB0-68A0-4BB8-8D82-F675C3624F6AQ27347987-57FDB2F7-33C8-4353-9832-734703B33FA6Q27666196-B9B3EC85-8C30-43A1-9FC3-1CC92632E05CQ28115009-32B720A0-EE2E-4D08-9312-2C4BC27D32D0Q28486603-25C5B4CF-87B3-4977-A549-35E17D44D74AQ28575279-14A64CA1-88FE-47EB-BBA5-1852D98A569FQ30008782-3C604B2F-6D3D-4EC5-9A79-E404EFCFD938Q30155988-C576866B-4903-4D6F-B721-56F193943835Q30157263-3B04368F-D3B8-4D67-B4E9-A60C8BFA6963Q30365066-6AD89526-F11D-4188-8972-C9BAA941CE35Q30407837-B9107711-3FDD-47CA-98DA-3B4BD3AFF43BQ30433191-BAC36CFB-6C00-49A3-9F2D-191B574DFE86Q33384767-7C30A138-DC5F-4839-B24E-3B1E9CAA9976Q33765534-A202065E-A699-474F-B44D-D3AAB227E632Q33827087-A4B33EAB-2EAA-46FF-BEF9-C58FB8FFC082Q33974356-6C9DD413-D7D4-4F1B-8178-7980A7A3CB8FQ34684685-0E453FA9-C8DF-4B70-B56D-3A9A08533922Q35555097-987E74B2-081F-4638-8578-FAE0A1F614EEQ36893771-4917271A-4F5F-43D1-A191-B9B21ABD0809Q37124244-E1401685-F15E-41B8-93FF-0FA5E60EBAA7Q38043712-9899EDE0-FC18-423C-B38F-1B6CB2106714Q38395145-BAF66272-E9A3-42DC-80A8-27D999B80840Q40478387-849D4EBD-FB1D-40B1-9260-68C745235C06Q41762394-48168E4F-2AAB-4BC4-BFE2-8AD287EF2CA2Q41911426-6ADC1F80-B535-4016-ADA5-AA26BBE7AD86Q42591638-43F98845-078E-4094-888F-286D65679FBEQ42636139-B8FDB7CD-F771-406D-9250-F26D4B35F275Q42724754-C44A027C-1BE1-4722-96BE-0751921BBAA8Q42849718-A263F30A-216F-4202-BD06-67BD9DAEB46AQ43648589-D810259D-BD2B-498D-852F-D6DB4F3FAA18Q46875861-3B057C92-BE6C-496C-9D21-B9CE5B53027BQ47643956-8016F82E-9BE7-4CE1-BE24-7500D9F2E474Q48156509-05D7F46F-1899-4D96-8528-AE0D1A6BD826Q51094903-009A6116-E575-4891-A1E1-99DFA3C2FD4A
P2860
Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Alanine-scanning mutagenesis d ...... itical for channel modulation.
@en
type
label
Alanine-scanning mutagenesis d ...... itical for channel modulation.
@en
prefLabel
Alanine-scanning mutagenesis d ...... itical for channel modulation.
@en
P2093
P2860
P1433
P1476
Alanine-scanning mutagenesis d ...... ritical for channel modulation
@en
P2093
Daniel L Minor
Kimberly A Clark
Michelle Wang
P2860
P304
P356
10.1016/J.STR.2007.11.010
P577
2008-02-01T00:00:00Z