Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones.
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Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesMolecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulationsCrystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperoneStructure and function of Hip, an attenuator of the Hsp70 chaperone cycleExploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.The human HSP70 family of chaperones: where do we stand?Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketSelective targeting of the stress chaperome as a therapeutic strategyAllostery in the Hsp70 chaperone proteinsRhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistanceHuman mitochondrial Hsp70 (mortalin): shedding light on ATPase activity, interaction with adenosine nucleotides, solution structure and domain organizationHsp70-Bag3 interactions regulate cancer-related signaling networksHSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.A modified HSP70 inhibitor shows broad activity as an anticancer agent.Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes.Anti-leukemia activity of a Hsp70 inhibitor and its hybrid moleculesProtein chaperones: a composition of matter review (2008 - 2013).A chaperone trap contributes to the onset of cystic fibrosis.Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome.A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseasesActivation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone ComplementA novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells.Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradationInducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages.Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In VivoActivation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradationChemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation.Allosteric heat shock protein 70 inhibitors block hepatitis C virus assemblyThe HSP70 family and cancerSynthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes.Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70Tau oligomers as potential targets for Alzheimer's diagnosis and novel drugsComparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets.Potential synergy between tau aggregation inhibitors and tau chaperone modulators.Heat shock protein 70 - the next chaperone to target in the treatment of human acute myelogenous leukemia?Hsp70 in cancer: back to the future.
P2860
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P2860
Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Allosteric drugs: the interact ...... 7 with human Hsp70 chaperones.
@en
type
label
Allosteric drugs: the interact ...... 7 with human Hsp70 chaperones.
@en
prefLabel
Allosteric drugs: the interact ...... 7 with human Hsp70 chaperones.
@en
P2093
P2860
P1476
Allosteric drugs: the interact ...... 7 with human Hsp70 chaperones.
@en
P2093
Aikaterini Rousaki
Chad A Dickey
Erik R P Zuiderweg
Jason E Gestwicki
Umesh K Jinwal
Yoshinari Miyata
P2860
P304
P356
10.1016/J.JMB.2011.06.003
P407
P577
2011-06-25T00:00:00Z