Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. - Wikidata - awgldk - TriplyDB

Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

http://www.wikidata.org/entity/Q41895360

about

Anterior thalamic paraventricular nucleus is involved in intermittent access ethanol drinking: role of orexin receptor 2.Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking.Drug-target residence time--a case for G protein-coupled receptors.The Role of Target Binding Kinetics in Drug Discovery.The Role of Orexin Signaling in the Ventral Tegmental Area and Central Amygdala in Modulating Binge-Like Ethanol Drinking Behavior.Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors.The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor.Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach.Hepatocellular carcinoma-targeted effect of configurations and groups of glycyrrhetinic acid by evaluation of its derivative-modified liposomes.From orphans to orexins: an arousing fifteen years.

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P2860

Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

http://www.wikidata.org/entity/Q41895360

description

2014 nî lūn-bûn

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Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

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Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

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Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

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British Journal of Pharmacology

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Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

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C J Langmead

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F H Marshall

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J Brown

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R Mould

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P2860

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Some quantitative uses of drug antagonists

Neurons containing hypocretin (orexin) project to multiple neuronal systems

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis.

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.

Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion.

Orexins and their receptors from fish to mammals: a comparative approach.

GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo

Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia.

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10.1111/BPH.12245

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2

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