Preclinical characterization of GSK2336805, a novel inhibitor of hepatitis C virus replication that selects for resistance in NS5A - Wikidata - awgldk - TriplyDB

Preclinical characterization of GSK2336805, a novel inhibitor of hepatitis C virus replication that selects for resistance in NS5A

Preclinical characterization of GSK2336805, a novel inhibitor of hepatitis C virus replication that selects for resistance in NS5A

http://www.wikidata.org/entity/Q41907539

about

Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection.Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients.Virology analysis in HCV genotype 1-infected patients treated with the combination of simeprevir and TMC647055/ritonavir, with and without ribavirin, and JNJ-56914845.Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein NS5A inhibitor resistance-associated polymorphisms in Brazilian treatment-naive patients infected with genotype 1 hepatitis C virus.Pharmacokinetics of hepatitis C virus NS5A inhibitor JNJ-56914845 (GSK2336805) in subjects with hepatic impairment.Global elimination of hepatitis C virus infection: Progresses and the remaining challenges.

P2860

Q35590547-67BDD4F9-F173-4256-AE2E-029C4A3EE70E Q36277394-E6749B42-F0E9-45AC-86AD-03B2861C09C4 Q37426527-6A9B236B-8ED3-456C-A5A8-1D5C5D597F04 Q38751552-6C1A86C0-EF24-4CB4-BCE6-FB3A589201A6 Q38844822-C8111863-D717-490D-9C3B-96AA05BA5889 Q41653846-CA58A41B-639E-46D8-805F-9D8E3C0B12BE Q42149746-2487CFE4-55F1-4BE5-852F-2A7B7367DBB4 Q47274792-86376B71-F8F5-407F-9E00-A92E6A8333A1

P2860

Preclinical characterization of GSK2336805, a novel inhibitor of hepatitis C virus replication that selects for resistance in NS5A

http://www.wikidata.org/entity/Q41907539

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Preclinical characterization o ...... selects for resistance in NS5A

@en

type

label

Preclinical characterization o ...... selects for resistance in NS5A

@en

prefLabel

Preclinical characterization o ...... selects for resistance in NS5A

@en

P1433

Q41907539-316D5DC5-B2E6-4198-AFCC-92F5E9718878

P1476

Q41907539-3FA76278-A3C7-4D44-9DB1-F9F2513C7767

P2093

Q41907539-0CA57F3A-907F-443F-BADA-003A19CB9F06

Q41907539-1E1EB7F1-316F-4E08-BCFC-B3A5AC8EE162

Q41907539-3025CB05-ED0F-45C6-B6A3-23513393061A

Q41907539-3061F82A-D18E-4090-A242-8434785C7500

Q41907539-3428CE27-715C-4093-BA8C-9561017F408F

Q41907539-3E93F6EB-75F8-4827-9A73-DF348CE4CA87

Q41907539-65271B4D-CA90-4C1D-8E12-11257A27389B

Q41907539-71806F87-237F-4462-A4EA-F1D34CE273F6

Q41907539-FFD807A1-EC54-499A-A1E5-EA1A7F6EF240

P2860

Q41907539-085DCF36-D1A3-46D7-B4B6-BC1DA83A591F

Q41907539-128AE9F4-D580-4B1B-A35A-E7AD407AF6AA

Q41907539-163CF1A9-6FCD-4AAF-9523-4DE746B8D614

Q41907539-1CB5FD52-55D6-4D28-A9BD-BA1CB493C1B8

Q41907539-223300A9-7987-4BBF-B911-F8966FDD3883

Q41907539-23E117C4-B8A1-4D7E-B4D1-6D7D0C57B71A

Q41907539-26C2DF5F-19D1-4D85-AC56-5487A53A44E4

Q41907539-26CF1C65-A9C3-4A36-867F-70E469A7E2C6

Q41907539-2818C6AC-8D20-450D-B3E5-466E5E4FBC44

Q41907539-28F64FB3-25B5-4071-ADA9-522A26DA74E1

P304

Q41907539-AB3DE7CA-B2F2-4A5A-8692-DDB77284C3D5

P31

Q41907539-8A19F415-A49D-4F68-80BA-7029C18DDD57

P356

Q41907539-251656DC-A589-45B2-A09F-47E498D77437

P407

Q41907539-A45C7584-4437-450B-9650-A3B0AC89A766

P433

Q41907539-FF84B87E-C641-489F-8D7A-412B63DA4CB7

P478

Q41907539-B2104D41-AE91-45AB-9CF7-42FB2EA4BA18

P50

Q41907539-4536A4EB-0F4D-4A24-B734-BD6115DD4851

Q41907539-8D0DC4A3-BDE3-48AE-81D4-1324E0DC1EDB

P577

Q41907539-726FA213-89BA-410C-8829-DBD2688C5299

P698

Q41907539-FEF44B5D-BF9A-4CB8-BA68-A176E3169302

P932

Q41907539-6E56FFD6-C45D-4856-AB88-652173636F85

P356

P1433

Antimicrobial Agents and Chemotherapy

P1476

Preclinical characterization o ...... selects for resistance in NS5A

@en

P2093

Amy Wang

http://www.w3.org/2001/XMLSchema#string

Ermias Woldu

http://www.w3.org/2001/XMLSchema#string

Jill Walker

http://www.w3.org/2001/XMLSchema#string

Katja Remlinger

http://www.w3.org/2001/XMLSchema#string

Maoshang Duan

http://www.w3.org/2001/XMLSchema#string

Renae Crosby

http://www.w3.org/2001/XMLSchema#string

Robert Hamatake

http://www.w3.org/2001/XMLSchema#string

Shihyun You

http://www.w3.org/2001/XMLSchema#string

Wieslaw Kazmierski

http://www.w3.org/2001/XMLSchema#string

P2860

Cellular cofactors affecting hepatitis C virus infection and replication

Clinical significance of hepatitis C virus genotypes

MUSCLE: multiple sequence alignment with high accuracy and high throughput

Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells.

Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase

Efficient Replication of Hepatitis C Virus Genotype 1a RNAs in Cell Culture

Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

Synergistic In Vitro Interactions between Alpha Interferon and Ribavirin against Bovine Viral Diarrhea Virus and Yellow Fever Virus as Surrogate Models of Hepatitis C Virus Replication

Identification of Residues Required for RNA Replication in Domains II and III of the Hepatitis C Virus NS5A Protein

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

P304

38-47

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/AAC.01363-13

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

58

http://www.w3.org/2001/XMLSchema#string

P50

Jessica Vamathevan

Christian Voitenleitner

P577

2013-10-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

24126581

http://www.w3.org/2001/XMLSchema#string

P932

3910799

http://www.w3.org/2001/XMLSchema#string