about
A cyclic peptide mimicking the third intracellular loop of the V2 vasopressin receptor inhibits signaling through its interaction with receptor dimer and G proteinTowards an evolutionary theory of the origin of life based on kinetics and thermodynamics5(4H)-oxazolones as intermediates in the carbodiimide- and cyanamide-promoted peptide activations in aqueous solution.The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor.An expeditious multigram-scale synthesis of lysine dendrigraft (DGL) polymers by aqueous N-carboxyanhydride polycondensation.Activation of carboxyl group with cyanate: peptide bond formation from dicarboxylic acids.Pathways for the formation and evolution of peptides in prebiotic environments.The origin of life: what we know, what we can know and what we will never know.Physicochemical Requirements Inferred for Chemical Self-Organization Hardly Support an Emergence of Life in the Deep Oceans of Icy Moons.Stability and its manifestation in the chemical and biological worlds.Mixed Anhydride Intermediates in the Reaction of 5(4H)-Oxazolones with Phosphate Esters and Nucleotides.How and why kinetics, thermodynamics, and chemistry induce the logic of biological evolution.Energy flows, metabolism and translation.Evolutionary importance of the intramolecular pathways of hydrolysis of phosphate ester mixed anhydrides with amino acids and peptides.A Strategy for Origins of Life Research.Active peptidic mimics of the second intracellular loop of the V(1A) vasopressin receptor are structurally related to the second intracellular rhodopsin loop: a combined 1H NMR and biochemical study.Dynamic co-evolution of peptides and chemical energetics, a gateway to the emergence of homochirality and the catalytic activity of peptides.Expression, purification and NMR characterization of the cyclic recombinant form of the third intracellular loop of the vasopressin type 2 receptor.On-line sample stacking of peptides in capillary electrophoresis for the study of prebiotic reactions between alpha,alpha-dialkylated amino acids and amino acid N-carboxyanhydrides.Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.Non-uniform surface charge distributions in CE: theoretical and experimental approach based on Taylor dispersion.The Activation of Free Dipeptides Promoted by Strong Activating Agents in Water Does not Yield Diketopiperazines.Energy sources, self-organization, and the origin of life.Antibody-based surfaces: rapid characterization using two complementary colorimetric assays.Dendrigraft poly-L-lysine: a non-immunogenic synthetic carrier for antibody production.Astrobiology and the Possibility of Life on Earth and Elsewhere…The Logic of LifeThe Peptide Formation Mediated by Cyanate Revisited.N-Carboxyanhydrides as Accessible Intermediates in the Decomposition ofN-Carbamoylamino Acids9. Life On Earth... And Elsewhere?5. Prebiotic Chemistry – Biochemistry – Emergence of Life (4.4–2 Ga)How Prebiotic Chemistry and Early Life Chose PhosphateThe Chemical Likelihood of Ribonucleotide-α-Amino acid Copolymers as Players for Early Stages of EvolutionMapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA.Do enzymes bind their substrates in the ground state because of a physico-chemical requirement?Amino acid N-carboxyanhydrides: activated peptide monomers behaving as phosphate-activating agents in aqueous solutionExpeditious, potentially primordial, aminoacylation of nucleotidesDesign and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRsA computational analysis of intramolecularity in proton transfer reactionsMonitoring clinical levels of heparin in human blood samples with an indicator-displacement assayDiastereoselectivity in prebiotically relevant 5(4H)-oxazolone-mediated peptide couplings
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Robert Pascal
@ast
Robert Pascal
@en
Robert Pascal
@es
Robert Pascal
@nl
Robert Pascal
@sl
type
label
Robert Pascal
@ast
Robert Pascal
@en
Robert Pascal
@es
Robert Pascal
@nl
Robert Pascal
@sl
prefLabel
Robert Pascal
@ast
Robert Pascal
@en
Robert Pascal
@es
Robert Pascal
@nl
Robert Pascal
@sl
P1053
O-1559-2013
P106
P21
P31
P3829
P496
0000-0001-9579-2503