Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21
about
Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cellsAn integrated disease/pharmacokinetic/pharmacodynamic model suggests improved interleukin-21 regimens validated prospectively for mouse solid cancers.A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles.Human cell-based artificial antigen-presenting cells for cancer immunotherapy.Specific roles of each TCR hemichain in generating functional chain-centric TCR.CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes.IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cellsIL-21 in cancer immunotherapy: At the right place at the right time.HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway.Induction of HLA-DP4-restricted anti-survivin Th1 and Th2 responses using an artificial antigen-presenting cell.
P2860
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P2860
Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Dissociation of its opposing i ...... nses induced by interleukin 21
@en
type
label
Dissociation of its opposing i ...... nses induced by interleukin 21
@en
prefLabel
Dissociation of its opposing i ...... nses induced by interleukin 21
@en
P2093
P2860
P1476
Dissociation of its opposing i ...... nses induced by interleukin 21
@en
P2093
Alla Berezovskaya
Andrew P Murray
Kristen Stevenson
Lee M Nadler
Marcus O Butler
Naoto Hirano
Sascha Ansén
P2860
P304
P356
10.1158/1078-0432.CCR-08-1146
P407
P577
2008-10-01T00:00:00Z