A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. - Wikidata - awgldk - TriplyDB

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

http://www.wikidata.org/entity/Q41912137

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Occurrence of pfatpase6 Single Nucleotide Polymorphisms Associated with Artemisinin Resistance among Field Isolates of Plasmodium falciparum in North-Eastern Tanzania Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network The interplay between drug resistance and fitness in malaria parasites Using genetic methods to define the targets of compounds with antimalarial activity Structural polymorphism in the promoter ofpfmrp2confersPlasmodium falciparumtolerance to quinoline drugs A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum PfCRT and its role in antimalarial drug resistance Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE Characterization of two putative potassium channels in Plasmodium falciparum Towards genome-wide experimental genetics in the in vivo malaria model parasite Plasmodium berghei Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum Antimalarial exposure delays Plasmodium falciparum intra-erythrocytic cycle and drives drug transporter genes expression Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)Glutathione transport: a new role for PfCRT in chloroquine resistance Chloroquine transport via the malaria parasite's chloroquine resistance transporter Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter Resistance to antimalarial drugs: molecular, pharmacologic, and clinical considerations.PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.Transporters involved in resistance to antimalarial drugs.Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes 4-aminoquinolines active against chloroquine-resistant Plasmodium falciparum: basis of antiparasite activity and quantitative structure-activity relationship analyses In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine High frequency of Plasmodium falciparum chloroquine resistance marker (pfcrt T76 mutation) in Yemen: an urgent need to re-examine malaria drug policy.Polymorphisms of molecular markers of antimalarial drug resistance and relationship with artesunate-mefloquine combination therapy in patients with uncomplicated Plasmodium falciparum malaria in Thailand.Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter.Monitoring PfMDR1 transport in Plasmodium falciparum.Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1 Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.Drug-resistant malaria Molecular epidemiology of drug resistance markers of Plasmodium falciparum in Yunnan Province, China.Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes.In vitro monitoring of Plasmodium falciparum drug resistance in French Guiana: a synopsis of continuous assessment from 1994 to 2005.Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.

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P2860

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

http://www.wikidata.org/entity/Q41912137

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2005年论文

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A critical role for PfCRT K76T ...... rsible chloroquine resistance.

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A critical role for PfCRT K76T ...... rsible chloroquine resistance.

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A critical role for PfCRT K76T ...... rsible chloroquine resistance.

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SJ.EMBOJ.7600681

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The EMBO Journal

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A critical role for PfCRT K76T ...... ersible chloroquine resistance

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Amar Bir Singh Sidhu

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David J Johnson

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Dominik Verdier-Pinard

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Donald J Krogstad

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George E Alakpa

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Patrick G Bray

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Rebecca A Muhle

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Ruth H Hughes

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Viswanathan Lakshmanan

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P2860

On the molecular mechanism of chloroquine's antimalarial action

Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates.

A molecular marker for chloroquine-resistant falciparum malaria.

The structure of malaria pigment beta-haematin.

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2294-2305

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10.1038/SJ.EMBOJ.7600681

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13

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David A. Fidock

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2005-06-09T00:00:00Z

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7797154

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15944738

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Plasmodium falciparum

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1173140

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