Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
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The ABCs of Candida albicans Multidrug Transporter Cdr1Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistanceProteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicansSphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance.Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints.The yeast sphingolipid signaling landscape.Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formationA potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis.Estimation of Candida albicans ABC Transporter Behavior in Real-Time via FluorescenceLipidomics and in vitro azole resistance in Candida albicans.A New Endogenous Overexpression System of Multidrug Transporters of Candida albicans Suitable for Structural and Functional Studies.The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but still lots to learn.Cell-type-specific transcriptional profiles of the dimorphic pathogen Penicillium marneffei reflect distinct reproductive, morphological, and environmental demands.Sphingolipid signaling in fungal pathogens.Lipids of Candida albicans and their role in multidrug resistance.Raft-like membrane domains in pathogenic microorganisms.Learning the ABC of oral fungal drug resistance.Analysis of sphingolipids, sterols and phospholipids in human pathogenic Cryptococcus strains.Plasma membrane lipids and their role in fungal virulence.Unraveling the role of membrane microdomains during microbial infections.Identification and functional characterization of Penicillium marneffei pleiotropic drug resistance transporters ABC1 and ABC2.Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species.ERG6 gene deletion modifies Kluyveromyces lactis susceptibility to various growth inhibitors.The RTA3 Gene, Encoding a Putative Lipid Translocase, Influences the Susceptibility of Candida albicans to Fluconazole.A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata.Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans.First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans.Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells.Lipid raft involvement in yeast cell growth and death.Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension.Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p.Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling.ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility.Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles.Synergistic activity of magnolol with azoles and its possible antifungal mechanism against Candida albicans.Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order.Fungicidal action of geraniol against Candida albicans is potentiated by abrogated CaCdr1p drug efflux and fluconazole synergism
P2860
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P2860
Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Multidrug transporters CaCdr1p ...... of CaCdr1p to membrane rafts.
@en
type
label
Multidrug transporters CaCdr1p ...... of CaCdr1p to membrane rafts.
@en
prefLabel
Multidrug transporters CaCdr1p ...... of CaCdr1p to membrane rafts.
@en
P2093
P2860
P356
P1476
Multidrug transporters CaCdr1p ...... of CaCdr1p to membrane rafts.
@en
P2093
Rajendra Prasad
Ritu Pasrija
Sneh Lata Panwar
P2860
P304
P356
10.1128/AAC.00861-07
P407
P577
2007-12-03T00:00:00Z