Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.
about
A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapieInhibition of RNA Recruitment and Replication of an RNA Virus by Acridine Derivatives with Known Anti-Prion ActivitiesThe prion protein binds thiamineAnti-prion activity of an RNA aptamer and its structural basisStructure-Based Drug Discovery for Prion Disease Using a Novel Binding SimulationVariety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity.Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparumEfficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.Pharmacological chaperone for the structured domain of human prion protein.Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.Prion protein-coated magnetic beads: synthesis, characterization and development of a new ligands screening method.Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases.Antiprion drugs as chemical tools to uncover mechanisms of prion propagation.Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life.Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells.Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments.Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease.Binding of TCA to the prion protein: mechanism, implication for therapy, and application as probe for complex formation of bio-macromolecules.Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue.Reactivity of 9-aminoacridine drug quinacrine with glutathione limits its antiprion activity.Pharmacological Agents Targeting the Cellular Prion Protein.
P2860
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P2860
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.
@en
type
label
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.
@en
prefLabel
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.
@en
P2093
P356
P1476
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.
@en
P2093
Bettina Elshorst
Christian Griesinger
Doris M Jacobs
Klaus Fiebig
Martin Vogtherr
Ralph Zahn
Susanne Grimme
P304
P356
10.1021/JM034093H
P407
P577
2003-08-01T00:00:00Z